One-pot three-component synthesis of quinazolines via a copper-catalysed oxidative amination reaction.

Org Biomol Chem

Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China and State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China.

Published: July 2016

AI Article Synopsis

  • A new method using copper as a catalyst allows for the creation of various quinazoline derivatives through a three-component reaction.
  • Solvents are utilized as reactants in this process, making it quite versatile.
  • The resulting products can be achieved in moderate to good yields while accommodating various functional groups.

Article Abstract

A copper-catalysed three-component reaction for constructing a series of quinazoline derivatives has been developed. In this system, solvents act as the reactants and different functional groups are well tolerated to obtain corresponding products in moderate to good yields.

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Source
http://dx.doi.org/10.1039/c6ob00625fDOI Listing

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