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The Role of IL-22 in Viral Infections: Paradigms and Paradoxes. | LitMetric

The Role of IL-22 in Viral Infections: Paradigms and Paradoxes.

Front Immunol

Institute of Infection and Immunity, Cardiff University, Cardiff, UK; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK.

Published: June 2016

Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885595PMC
http://dx.doi.org/10.3389/fimmu.2016.00211DOI Listing

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