Eccrine porocarcinoma is a rare malignant sweat gland tumor arising from the intra dermal part of the gland and accounts for only 0.005% of all epithelial cutaneous tumors. Commonly involved site includes extremities and face. Scalp is a rare site for porocarcinoma with less than 20 reported cases so far. Wide local excision with clear margins remains the treatment of choice. Review of literature revealed a local recurrence rate of 37.5% and a nodal involvement risk of 20%. Porocarcinoma of the scalp is peculiar in that the primary tumor may be large at presentation, making surgery with adequate margins difficult. Adjuvant radiotherapy must be considered in a case to case basis due to the high local recurrence rates compared to other sites of porocarcinoma and should be given to all patients with close margins and extra capsular extension.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jnci.2016.05.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Navigating Head and Neck Porocarcinoma: Systematic Review with Special Emphasis on Surgical Safety Margins.
Cancers (Basel)
March 2024
Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Article Synopsis
- - Eccrine porocarcinoma is a complex skin tumor that can be difficult to diagnose, often requiring surgical excision for both diagnosis and treatment, with inconsistent data on surgical safety margins.
- - A systematic review analyzed 18 studies focused on surgical margins for porocarcinoma cases in the head and neck area, finding that most cases were in facial regions and on the scalp, with safety margins averaging 10.1 mm.
- - The review concluded that larger tumors typically require wider safety margins, but the lack of consistent safety margin reporting across studies highlights the need for further research and standardized guidelines.
Article Synopsis
- A 23-year-old South Asian man developed a darkly pigmented papule on his scalp, which grew within a pre-existing warty plaque present since birth.
- The papule showed characteristics indicative of basal cell carcinoma (BCC) when examined and biopsied, confirming it developed from a sebaceous naevus.
- Sebaceous naevi are benign skin lesions that can develop into malignancies like BCC in a small percentage of cases, especially in adults.
Fusion-driven cutaneous and superficial mesenchymal and adnexal tumors-A clinicopathologic and molecular study of 15 cases, including a novel case of ACTB::ZMIZ2-rearranged adnexal carcinoma.
J Cutan Pathol
July 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Article Synopsis
- The study explores the challenges of diagnosing fusion-driven soft tissue neoplasms, particularly those with unclear histopathology, which makes classification difficult.
- The researchers aimed to assess the effectiveness of next-generation sequencing in accurately diagnosing complex cutaneous neoplasms by examining various cases from departmental archives.
- Results included 15 cases across various demographics, revealing significant fusion events that can aid in identifying rare tumor types, thus highlighting the potential of molecular testing in improving diagnostic accuracy.
Porocarcinoma with orbital metastasis, a case report with review of literature.
Orbit
October 2024
Orbit and Oculofacial Surgery/Ophthalmic Oncology, Department of Ophthalmology, National University Hospital, Singapore, Singapore.
We present a patient who presented with an orbital mass lesion which was a metastatic lesion from a porocarcinoma of the scalp with progressive deterioration of the patient.A 78-year-old male presented with functional decline and a rapidly growing scalp lesion of 3 months duration. In addition to the scalp lesion, Computed Tomography showed an incidental finding of a left lateral orbital wall tumour.
View Article and Find Full Text PDFPorocarcinoma with YAP1-NUTM1 fusion presenting as a NUT immunohistochemistry-positive lymph node metastasis.
J Cutan Pathol
May 2023
Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Introduction: Porocarcinoma is a rare, malignant adnexal tumor that recently has been shown to contain YAP1-NUTM1 and YAP1-MAML2 fusion transcripts, with nuclear protein in testis (NUT) immunohistochemistry (IHC) positivity in a subset of these tumors. Consequently, NUT IHC may either aid in the differential diagnosis, or represent a confounding factor depending on the clinical scenario. Here, we present a case of NUTM1-rearranged sarcomatoid porocarcinoma of the scalp presenting as a NUT IHC-positive lymph node metastasis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!