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PGT-A: what's it for, what's wrong?
J Assist Reprod Genet
January 2025
Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
PGT-A, what's it for? Considering the increase in fetal aneuploidies with a woman's age and the high number of miscarriages associated with fetal karyotype anomalies, the concept of selecting IVF embryos based on their karyotype in order to transfer only euploid embryos and eliminate aneuploid ones was proposed. Preimplantation genetic testing for aneuploidy (PGT-A) was then established, nearly 30 years ago, with the expectation that the transfer of euploid embryos would lead to a significant improvement in medically assisted reproduction (MAR) outcomes. PGT-A, what's wrong? Despite the practice and widespread use, PGT-A has not consistently proven its effectiveness.
View Article and Find Full Text PDFThe GP athlete: what's the best advice I can give my patients about nutrition?
Br J Gen Pract
January 2025
Leeds-based GP, National Institute for Health and Care Research Doctoral Research Fellow at the University of Leeds, and a recent BJGP & BJGP Open Editorial Fellow. Email:
Sex and Gender Considerations in Orthopaedic Research: Existing Barriers, What's Needed by Institutions and Research Departments, and How to Guide Junior Investigators and Faculty.
J Bone Joint Surg Am
October 2024
Office of Research on Women's Health, National Institutes of Health, Bethesda, Maryland.
Article Synopsis
- The JBJS symposium focused on the importance of including sex and gender in orthopaedic research to enhance study methods and patient outcomes, addressing current shortcomings in reporting.
- Barriers to proper reporting stem from cultural resistance, inadequate education on terminology and study design, insufficient funding for larger studies, and the need for better understanding of how biological and social factors like gender and race interact in health research.
- To overcome these challenges, the development of best-practice statistical methods and ongoing education for all stakeholders in research is crucial, with existing guidelines like the SAGER providing a framework for improvement and support from academic institutions and funders being essential for meaningful progress.
Drugs stimulating insulin secretion in early clinical development for the treatment of type 1 diabetes: what's new?
Expert Opin Investig Drugs
December 2024
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Introduction: Type 1 diabetes is a chronic autoimmune condition characterized by the selective destruction of insulin-producing beta cells in the pancreas. The etiology of T1D is multifactorial, with a combination of genetic susceptibility and environmental triggers believed to underlie beta-cell destruction. Preserving and prolonging beta-cell function in T1D is a pivotal therapeutic objective that can mitigate disease progression and improve glycemic control.
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