AI Article Synopsis
- The aim of the study was to analyze the clinical outcomes and management strategies for lymph nodes extrapulmonary small cell carcinoma (LNEPSCC) through a systematic literature review.
- The research identified eight studies focusing on 14 patients, with 64.7% presenting limited disease and treated mainly with chemotherapy or surgery; 70.6% achieved a complete response.
- The findings suggest that while LNEPSCC is rare, patients with limited disease can undergo successful surgical treatment, and those with extensive disease benefit from platinum-based chemoradiation, leading to better prognosis compared to small cell lung cancer.
Article Abstract
Aim: To study clinical outcomes and management of lymph nodes extrapulmonary small cell carcinoma (LNEPSCC).
Methods: Herein, we perform a systematic search of published literature in the PubMed and EMBASE databases for studies describing LNEPSCC. For uniformity of reporting, LNEPSCC was staged as limited if it involved either single lymph node station or if surgery with curative intent had been undertaken. The disease was staged extensive if it involved two or more lymph node regions.
Results: The systematic literature review yielded eight descriptions (n = 14) involving cervical, submandibular and inguinal lymph nodes. Eleven (64.7%) patients had limited disease (LD) and six (35.3%) had extensive disease (ED) at presentation. Chemotherapy (n = 6, 35.3%) or surgery (n = 4, 23.5%) were the most common form of treatment given to these patients. Complete response was achieved in 12 (70.6%) of the patients. Median (interquartile range) progression free survival and overall survival was 15 (7-42) mo and 22 (12.75-42) mo respectively. Of the three illustrative cases, two patients each had ED at presentation and achieved complete remission with platinum based combination chemotherapy.
Conclusion: LNEPSCC is a rare disease with less than 15 reported cases in world literature. Surgical resection with curative intent is feasible in those with LD while platinum based combination chemoradiation is associated with favorable outcomes in patients with ED. Prognosis of LNEPSCC is better than that of small cell lung cancer in general.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896899 | PMC |
| http://dx.doi.org/10.5306/wjco.v7.i3.308 | DOI Listing |
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