AI Article Synopsis
- Cytogenetic abnormalities are common in acute lymphoblastic leukemia (ALL) and are often linked to a poor prognosis.
- Advanced techniques like spectral karyotyping (SKY) enhance the analysis of chromosomal abnormalities compared to traditional methods like R-banding.
- The study highlighted the successful use of SKY in identifying specific genetic changes in an adult patient with ALL, showing its potential for better predicting disease outcomes.
Article Abstract
Cytogenetic abnormalities are frequently detected in patients with acute lymphoblastic leukemia (ALL). Comprehensive karyotype was related to poor prognosis frequently in ALL. We present a comprehensive karyotype in an adult ALL by spectral karyotyping (SKY) and R-banding. SKY not only confirmed the abnormalities previously seen by R-banding but also improved comprehensive karyotype analysis with the following result 47,XY,+9, ins(1;5)(q23;q23q34) t(6;7)(q23;p13). Our report demonstrated that SKY is able to provide more information accurately for prediction of disease prognosis in adult ALL with comprehensive karyotype.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897657 | PMC |
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