AI Article Synopsis
- The study showcases a method called Coulomb explosion imaging (CEI) that determines the absolute configuration of small molecules in the gas phase using X-ray photon ionization.
- It highlights that using a synchrotron light source improves efficiency and speeds up fragmentation compared to older techniques that use femtosecond lasers.
- Additionally, it points out that even partially fragmented molecules from a racemic sample can still provide information on absolute configuration, making the method more versatile for analyzing larger chiral molecules.
Article Abstract
The absolute configuration of individual small molecules in the gas phase can be determined directly by light-induced Coulomb explosion imaging (CEI). Herein, this approach is demonstrated for ionization with a single X-ray photon from a synchrotron light source, leading to enhanced efficiency and faster fragmentation as compared to previous experiments with a femtosecond laser. In addition, it is shown that even incomplete fragmentation pathways of individual molecules from a racemic CHBrClF sample can give access to the absolute configuration in CEI. This leads to a significant increase of the applicability of the method as compared to the previously reported complete break-up into atomic ions and can pave the way for routine stereochemical analysis of larger chiral molecules by light-induced CEI.
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| http://dx.doi.org/10.1002/cphc.201501118 | DOI Listing |
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