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Tracheobronchial carcinoid tumour causing a complete collapse of the one and compensatory hypertrophy of the other lung, resulting in a postpneumonectomy-like syndrome.
BMJ Case Rep
May 2022
Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
Genome-wide expression of the residual lung reacting to experimental Pneumonectomy.
BMC Genomics
December 2021
Department of Thoracic Surgery, University of Rome Sapienza, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Background: Acute or chronic irreversible respiratory failure may occur in patients undergoing pneumonectomy. Aim of this study was to determine transcriptome expression changes after experimental pneumonectomy in swine model. Experimental left pneumonectomy was performed in five pigs under general anaesthesia.
View Article and Find Full Text PDFInvestigation of the mechanisms of VEGF-mediated compensatory lung growth: the role of the VEGF heparin-binding domain.
Sci Rep
June 2021
Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Morbidity and mortality for neonates with congenital diaphragmatic hernia-associated pulmonary hypoplasia remains high. These patients may be deficient in vascular endothelial growth factor (VEGF). Our lab previously established that exogenous VEGF164 accelerates compensatory lung growth (CLG) after left pneumonectomy in a murine model.
View Article and Find Full Text PDFInhalational delivery of induced pluripotent stem cell secretome improves postpneumonectomy lung structure and function.
J Appl Physiol (1985)
November 2020
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Cell-free secretory products (secretome) of human induced pluripotent stem cells (iPSCs) have been shown to attenuate tissue injury and facilitate repair and recovery. To examine whether iPSC secretome facilitates mechanically induced compensatory responses following unilateral pneumonectomy (PNX), litter-matched young adult female hounds underwent right PNX (removing 55%-58% of lung units), followed by inhalational delivery of either the nebulized-conditioned media containing induced pluripotent stem cell secretome (iPSC CM) or control cell-free media (CFM); inhalation was repeated every 5 days for 10 treatments. Lung function was measured under anesthesia pre-PNX and 10 days after the last treatment (8 wk post-PNX); detailed quantitative analysis of lung ultrastructure was performed postmortem.
View Article and Find Full Text PDFErythropoietin inhalation enhances adult canine alveolar-capillary formation following pneumonectomy.
Am J Physiol Lung Cell Mol Physiol
May 2019
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Paracrine erythropoietin (EPO) signaling in the lung recruits endothelial progenitor cells, promotes cell maturation and angiogenesis, and is upregulated during canine postpneumonectomy (PNX) compensatory lung growth. To determine whether inhalational delivery of exogenous EPO augments endogenous post-PNX lung growth, adult canines underwent right PNX and received, via a permanent tracheal stoma, weekly nebulization of recombinant human EPO-containing nanoparticles or empty nanoparticles (control) for 16 wk. Lung function was assessed under anesthesia pre- and post-PNX.
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