Instrumental activities scales allow the assessment of the functional status of the elderly; however, those currently used have gender bias and insufficient cross-cultural validation. The main objectives of this study were to perform the cross-cultural validation of the modified "VIDA: Daily living of the elderly questionnaire", created in Spain, into the Spanish spoken language in the City of Buenos Aires, and to evaluate its telephonic reliability. The secondary objective was to assess the concurrent validity of the modified VIDA questionnaire with the Lawton and Brody scale. The experts discussion group assessed the questionnaire vocabulary and proposed modifications according to the local language. We performed a pilot study to evaluate its comprehension, vocabulary and length. Afterwards we interviewed patients in person and after 14 days by telephone. We analyzed the global, inter and intra-observer reliability in both, the in person and the telephonic questionnaire, obtaining intra-class correlation coefficients of 0.95 (CI 95% 0.91-0.99), 0.99 (CI 95% 0.97-1.00) and 0.94 (IC 95% 0.87-1.00) respectively. Additionally, we obtained a very good correlation in both modalities between the modified VIDA questionnaire and the Lawton and Brody scale, with no differences regarding the patient's gender. In conclusion, the modified VIDA questionnaire was cross-culturally adapted in Buenos Aires City. Its implementation is reliable and valid both in person and by telephone.
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Chemosphere
December 2024
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Escola Politécnica, Laboratório de Organometálicos e Resinas, Porto Alegre, RS, Brazil. Electronic address:
This study developed a biodegrading additive based on nanosilica and modified by cellulase enzyme in the presence of citric acid and sodium citrate. The additive was tested as a facilitator for biodegradation of the commercial low-density polyethylene (LDPE) in soil. Enzyme immobilization was confirmed by enzymatic assays.
View Article and Find Full Text PDFSemergen
December 2024
Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, Burjassot, València, Spain; CIBER of Epidemiology and Public Health, Carlos III Health Institute, Madrid, Spain.
While acute myocardial infarction is rare in children, a part of the pediatric population is at a higher risk due to preexisting non-modifiable conditions. To mitigate the risk, modifiable risk factors such as unhealthy diet or sedentary lifestyle should be controlled from childhood, promoting healthy habits from the earliest stages. The primary purpose of this review is to assess the evidence on lifestyle/nutrition related modifiable risk factor intervention on the risk of acute myocardial infarction in children found in four databases, PubMed, Embase, Scopus and WoS.
View Article and Find Full Text PDFMar Environ Res
December 2024
Departamento de Ecología y Biodiversidad, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile; Centro de Investigaciones Marinas de Quintay, Universidad Andres Bello, Santiago, Chile. Electronic address:
Upwelling, as a large oceanographic phenomenon, increases coastal productivity and influences all levels of biological complexity. Despite decades of research on it, much remains to be understood about the impact of upwelling on the feeding behavior and thermal tolerance of important groups such as fish. Hence, our aim was to investigate how upwelling conditions modify the feeding behavior and thermal tolerance of a prominent intertidal fish, Girella laevifrons.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA 90095.
Combining a T cell-targeting mRNA vaccine encoding the conserved SARS-CoV-2 RNA-dependent RNA polymerase, RdRp, with a Spike-encoding mRNA vaccine may offer an additional pathway toward COVID-19 protection. Here, we show that a nucleoside-modified RdRp mRNA vaccine raises robust and durable CD8+ T cell responses in mice. Immunization drives a CD8+ T cell response enriched toward a specific RdRp epitope.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
November 2024
Instituto de Biologia, Universidade Federal de Uberlândia, Uberlândia 38402-018, Minas Gerais, Brazil.
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