The synthesis and characterization of eight unprecedented phosphorescent C^C* cyclometalated mesoionic aryl-1,2,3-triazolylidene platinum(II) complexes with different β-diketonate ligands are reported. All compounds proved to be strongly emissive at room temperature in poly(methyl methacrylate) films with an emitter concentration of 2 wt %. The observed photoluminescence properties were strongly dependent on the substitution on the aryl system and the β-diketonate ligand. Compared to acetylacetonate, the β-diketonates with aromatic substituents (mesityl and duryl) were found to significantly enhance the quantum yield while simultaneously reducing the emission lifetimes. Characterization was carried out by standard techniques, as well as solid-state structure determination, which confirmed the binding mode of the carbene ligand. DFT calculations, carried out to predict the emission wavelength with maximum intensity, were in excellent agreement with the (later) obtained experimental data.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201601060 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the Structure-Activity Relationships of Albumin-Targeted Picoplatin-Based Platinum(IV) Prodrugs.
Inorg Chem
January 2025
Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Platinum(II) complexes prevail as first-line treatment for many cancers but are associated with serious side effects and resistance development. Picoplatin emerged as a promising alternative to circumvent GSH-induced tumor resistance by introducing a bulky 2-picoline ligand. Although clinical studies were encouraging, picoplatin did not receive approval.
View Article and Find Full Text PDFImpacts of amino acid-linked platinum(II) complexes on DNA structure.
J Biol Inorg Chem
January 2025
Department of Chemistry, Wayne State University, Detroit, MI, USA.
The discovery of cisplatin (cisPt) as an effective anticancer agent was a milestone in the health industry. Despite its success, undesired side effects and acquired resistance still limit the therapeutic usefulness of cisPt. Intrastrand adduct formation at consecutive purines and structural modifications of DNA caused by platinum(II) complexes are important factors for antitumor efficacy.
View Article and Find Full Text PDFReversible Piezochromism of Platinum(II) and Palladium(II) Dimers in Molecular Single Crystals.
Nano Lett
January 2025
Institute of Physics, Center for Nanotechnology (CeNTech), University of Münster, 48149 Münster, Germany.
Transition metal complexes are well-known for their efficient light emission and are promising for applications ranging from bioimaging to light-emitting diodes. In solution, interactions between the metal centers of two complexes become possible and drastically change the photophysical properties. For real-world devices, solid-state materials consisting of these molecules are preferable.
View Article and Find Full Text PDFRecent advances in ruthenium (III) complex-loaded nanomaterial for enhanced cancer therapy efficacy.
Drug Dev Ind Pharm
January 2025
Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin, China.
Objective: Amid the escalating global cancer incidence, the development of effective and safe anticancer drugs is a critical priority in medical research. Addressing the clinical shortcomings of ruthenium-based anticancer drugs are currently a prominent focus of research.
Significance And Methods: Since the pioneering work with platinum derivatives, significant progress has been made in the fundamental studies of metal complexes for the treatment of a wide range of cancers, and there has been a growing interest in their properties and biomedical applications.
Carbazolylpyridine ()-based tetradentate platinum(II) complexes containing fused 6/5/6 metallocycles.
Dalton Trans
January 2025
College of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P. R. China.
A series of carbazolylpyridine ()-based 6/5/6 Pt(II) complexes featuring tetradentate ligands with nitrogen or oxygen atoms as bridging groups was designed and synthesized, and the bridging nitrogen atoms were derived from acridinyl (Ac), azaaceridine (AAc) and carbazole (Cz). Systematic experimental and theoretical studies reveal that the ligand structures have a significant effect on the electrochemical, photophysical and excited state properties of these complexes. Their oxidation processes mainly occur on the carbazole-Pt moieties, whereas the reduction processes typically occur on the electron-deficient pyridine (Py) moieties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!