AI Article Synopsis
- Trypanosomosis is a significant parasitic disease impacting livestock in tropical areas, particularly in Latin America, with Trypanosoma vivax being the primary cause of ruminant infections.
- The study focused on how T. vivax affects ovine red blood cells (RBCs), observing changes in shape and surface structure due to interactions with the parasite.
- These alterations lead to increased removal of the damaged RBCs by the immune system, resulting in a decrease in hematocrit levels during the infection.
Article Abstract
Trypanosomosis, a globally occurring parasitic disease, poses as a major obstacle to livestock production in tropical and subtropical regions resulting in tangible economic losses. In Latin America including Venezuela, trypanosomosis of ruminants is mainly caused by Trypanosoma vivax. Biologically active substances produced from trypanosomes, as well as host-trypanosome cellular interactions, contribute to the pathogenesis of anemia in an infection. The aim of this study was to examine with a scanning electron microscope the cellular interactions and alterations in ovine red blood cells (RBC) experimentally infected with T. vivax. Ovine infection resulted in changes of RBC shape as well as the formation of surface holes or vesicles. A frequent observation was the adhesion to the ovine RBC by the trypanosome's free flagellum, cell body, or attached flagellum in a process mediated by the filopodia emission from the trypanosome surface. The observed RBC alterations are caused by mechanical and biochemical damage from host-parasite interactions occurring in the bloodstream. The altered erythrocytes are prone to mononuclear phagocytic removal contributing to the hematocrit decrease during infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884851 | PMC |
| http://dx.doi.org/10.1155/2016/4503214 | DOI Listing |
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