AI Article Synopsis
- Congenital myopathies (CMs) are often treated as separate disorders; however, this study found that some cases have overlapping characteristics, specifically central nuclei, nemaline rods, and cores.
- The researchers analyzed 125 previously diagnosed CM cases and discovered that 12% exhibited multiple morphological features, indicating that initial diagnoses may have overlooked additional pathologies.
- Recognizing these overlapping features is important for accurate diagnosis and understanding the complex nature of congenital myopathies, which include conditions like centronuclear myopathy and nemaline rod myopathy.
Article Abstract
Background: Congenital myopathies (CMs) though considered distinct disorders, simultaneous occurrence of central nucleus, nemaline rods, and cores in the same biopsy are scarcely reported.
Objective: A retrospective reassessment of cases diagnosed as CMs to look for multiple pathologies missed, if any, during the initial diagnosis.
Materials And Methods: Enzyme histochemical, and immunohistochemical-stained slides from 125 cases diagnosed as congenital myopathy were reassessed.
Results: The study revealed 15 cases (12%) of congenital myopathy with more than one morphological feature. Central nucleus with cores (n = 11), central nucleus, nemaline rods and cores (n = 3), and nemaline rods with cores (n = 1). 4/11 cases were diagnosed as centronuclear myopathy (CNM) in the first instance; in addition, cores were revealed on reassessment.
Discussion: The prevalence of CMs of all neuromuscular disorders is approximately 6 in 100,000 live births, with regional variations. Three main defined CMs include centro nuclear myopathy (CNM), nemaline rod myopathy (NRM), and central core disease (CCD). However, they are more diverse with overlapping clinical and histopathological features, thus broadening the spectra within each category of congenital myopathy.
Conclusion: Identification of cases with overlap of pathological features has diagnostic relevance.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888682 | PMC |
| http://dx.doi.org/10.4103/0972-2327.176861 | DOI Listing |
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