AI Article Synopsis
- Neonatal blueberry muffin lesions are rare skin eruptions characterized by red-violaceous papules, often linked to congenital infections and blood disorders, but this report introduces a novel association with maternal severe anemia during pregnancy.
- A case is presented of a male neonate with these lesions, high levels of red blood cells, and brain ultrasound abnormalities, suggesting a connection to chronic hypoxia caused by the mother's anemia.
- The findings propose that fetal hypoxia from severe maternal anemia could contribute to the emergence of these lesions, highlighting an unrecognized cause for this dermatological condition.
Article Abstract
Background: Neonatal blueberry muffin lesions are rare cutaneous eruptions, presenting as transient, non-blanching, red-violaceous papules, mostly localized in the trunk, head and neck, attributable to a marked dermal hematopoietic activity. Congenital infections of the TORCH complex (toxoplasmosis, other, rubella, cytomegalovirus and herpes) and hematological disorders have been classically associated with this neonatal dermatological manifestation. We report for the first time an unusual presentation of blueberry muffin lesions in a neonate born from a mother affected by severe anemia during pregnancy.
Case Presentation: A male, white Caucasian, neonate showed a cutaneous rash at birth, suggestive of "blueberry muffin"-like lesions. These cutaneous lesions were associated with marked elevation of the circulating nucleated red blood cells, and with ultrasound findings of peculiar brain ischemic porencephalic lesions. The clinical features of spontaneous disappearance and the association with marked erythroblastosis strongly suggest that these dermatological findings may be the consequence of an extramedullary hematopoiesis unexpectedly evoked by the intrauterine chronic exposure to hypoxia caused by severe maternal anemia.
Conclusions: In conclusion, fetal hypoxia secondary to severe maternal anemia may play a causative and unreported role in the development of neonatal blueberry muffin lesions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904358 | PMC |
| http://dx.doi.org/10.1186/s13256-016-0924-5 | DOI Listing |
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