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Strategies for Increasing the Solubility and Bioavailability of Anticancer Compounds: β-Lapachone and Other Naphthoquinones. | LitMetric

AI Article Synopsis

  • Quinones are highly researched due to their significant biological potential, showing effectiveness against various microorganisms and tumor cells.
  • Some quinones have been developed into clinically used drugs, but they face challenges like solubility, stability, and toxicity.
  • Controlled-release systems have been used to enhance the pharmacological properties of quinones, showing promising results in improving their effectiveness and safety.

Article Abstract

Quinones are among the most studied natural and synthetic products in the literature because they have considerable biological potential. These compounds exhibit activity against many microorganisms and are able to eliminate tumor cells through several mechanisms of action. Some of these compounds have become drugs that are used clinically. However, they also have problems with respect to solubility, stability and toxicity. The alternative of using controlled-release systems has been applied to quinones, with good results in some cases, indicating that these formulations may be a strategy for improving the pharmacological profile of this class of compounds.

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Source
http://dx.doi.org/10.2174/1381612822666160611012532DOI Listing

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