AI Article Synopsis
- The study discusses how colloidal CdSe quantum dots (QDs) are transformed from hydrophobic to hydrophilic by coating them with long peptide chains from membrane scaffold proteins (MSP).
- The process involves initial solubilization of QDs using detergents, with n-octyl glucoside being particularly effective, and analyses reveal that the resulting QD-MSP conjugates are mostly discoidal in shape, formed by single QDs surrounded by helical peptide belts.
- Fourier-transform infrared spectroscopy shows that the proteins maintain their structure during conjugate formation, and the resulting QD-MSP conjugates exhibit enhanced stability in water, paving the way for future research on single peptide-coated QDs.
Article Abstract
Here, the transition of colloidal CdSe quantum dots (QDs) from hydrophobic to hydrophilic environments after coating the surface with long peptide chains of membrane scaffold proteins (MSP) is reported. The intermediate step included the solubilization of QDs with detergents, where n-octyl glucoside was the most promising ligand. Furthermore, size analysis by fluorescence correlation spectroscopy, gel filtration and atomic force microscopy suggested that the obtained QD-MSP conjugates were primarily discoidal and were likely formed from single QDs tightly encircled by helix belts. In addition, Fourier-transformed infrared spectroscopy analysis confirmed the preservation of the secondary structure of most proteins during conjugate formation, with no signs of denaturation. The obtained QD-MSP conjugates were optimal in terms of stability in water environments, suggesting that it is possible to obtain QDs with single peptide coats and providing the first guidelines for future research in this direction.
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| http://dx.doi.org/10.1016/j.colsurfb.2016.05.081 | DOI Listing |
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