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Saturated fat in an evolutionary context.
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Institute of Health, Oslo New University College, Ullevålsveien 76, Oslo, 0454, Norway.
Evolutionary perspectives have yielded profound insights in health and medical sciences. A fundamental recognition is that modern diet and lifestyle practices are mismatched with the human physiological constitution, shaped over eons in response to environmental selective pressures. This Darwinian angle can help illuminate and resolve issues in nutrition, including the contentious issue of fat consumption.
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National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, especially after the global circulation of BA.2.86/JN.
View Article and Find Full Text PDFActivation of lysophagy by a TBK1-SCF-TMEM192-TAX1BP1 axis in response to lysosomal damage.
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School of Life Sciences, BK21 FOUR KNU Creative BioRearch Group, Kyungpook National University, Daegu, South Korea.
Lysophagy eliminates damaged lysosomes and is crucial to cellular homeostasis; however, its underlying mechanisms are not entirely understood. We screen a ubiquitination-related compound library and determine that the substrate recognition component of the SCF-type E3 ubiquitin ligase complex, SCF(FBXO3), which is a critical lysophagy regulator. Inhibition of FBXO3 reduces lysophagy and lysophagic flux in response to L-leucyl-L-leucine methyl ester (LLOMe).
View Article and Find Full Text PDFGrowth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats.
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Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
The present study investigated the impact of GABAergic signaling and miRNA expression on glioblastoma multiforme (GBM) growth within the medial prefrontal cortex (mPFC) and its associated cognitive and emotional impairments. The implantation of C6 cells into the mPFC induced GBM in this brain region (referred to as the mPFC-GBM) in male Wistar rats via stereotaxic surgery, as confirmed by Magnetic Resonance Imaging (MRI), and Hematoxylin and Eosin (H&E) staining. Repeated microinjections of muscimol, a potent GABA receptor agonist, directly into the mPFC-GBM (1µg/rat/2.
View Article and Find Full Text PDFA novel separated OPECT aptasensor based on MOF-derived BiVO/BiS type-II heterojunction for rapid detection of bacterial quorum sensing signal molecules.
Talanta
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Qingdao Key Laboratory of Analytical Technology Development and Offshore Eco-Environment Conservation, Marine Bioresource and Environment Research Center, First Institute of Oceanography, Ministry of Natural Resources, No. 6 Xianxialing Road, Qingdao, 266061, PR China. Electronic address:
Quorum sensing signal molecules released by microorganisms serve as critical biomarkers regulating the attachment and aggregation of marine microbes on engineered surfaces. Hence, the development of efficient and convenient methods for detecting quorum sensing signal molecules is crucial for monitoring and controlling the formation and development of marine biofouling. Advanced optoelectronic technologies offer increased opportunities and methods for detecting quorum sensing signal molecules, thereby enhancing the accuracy and efficiency of detection.
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