Plasma melatonin circadian profiles were investigated in a group of 4 patients with anorexia nervosa and 4 healthy regularly cycling women. There were no differences in the mean age of both groups, whereas the anorexia nervosa patients had lower mean body weight (37.8 +/- 2.0 vs 57.0 +/- 4.9 kg) and body mass index (13.9 +/- 1.1 vs 20.8 +/- 2.0). Samples were collected every 2 h and plasma melatonin was measured by using a RIA with an iodinated tracer. Anorexia nervosa patients exhibited higher diurnal (60.7 +/- 1.8 vs 25.4 +/- 1.72 pmol/l, P less than 0.02) and nocturnal (419.2 +/- 37.4 vs 108.0 +/- 33.6 pmol/l), P less than 0.001) mean plasma melatonin concentrations. There were no differences in the time peak for nocturnal melatonin secretion in both groups, detected at 02.00 h. In anorexia nervosa, the melatonin circadian profile paralleled that observed in the control group, indicating that the increased melatonin values for anorexia nervosa were probably due to an enhanced secretory pineal function rather than an impaired melatonin metabolism. These results suggest a participation of the pineal gland in the pathophysiology of anorexia nervosa.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1530/acta.0.1200574 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Obsessive-compulsive symptoms in individuals with a history of eating disorders.
J Affect Disord
January 2025
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; School of Population Health, Curtin University, Perth, Western Australia, Australia; Division of Paediatrics, School of Medicine, The University of Western Australia, Perth, Western Australia, Australia. Electronic address:
Background: OCD symptoms are well documented in anorexia nervosa (AN) and to a lesser extent in bulimia nervosa (BN), yet remain virtually unstudied in binge-eating disorder (BED).
Methods: In this cross-sectional observational study, 5927 participants with lifetime eating disorders (EDs) (i.e.
A Bitter Pill: The Ethics of Involuntary Treatment of Adolescents With Severe Eating Disorders.
Hosp Pediatr
January 2025
Departments of Medicine and Ethics, University of Vermont Medical Center, Burlington, Vermont.
Severe eating disorders (EDs) are a common and increasing threat to normal adolescent health and development. Major clinical challenges include longstanding malnutrition potentially complicated by emergent electrolyte disorders and cardiac dysfunction. The care of adolescents with severe EDs can lead to challenging decisions regarding the initiation of involuntary feeding with restraints.
View Article and Find Full Text PDFTranslation and Adaptation of the SCOFF Questionnaire to the Greek Language (G-SCOFF) Using a Tertiary-Setting Adolescent Sample.
Nutrients
January 2025
Department of Nutrition, General Hospital of Thessaloniki "G. Gennimatas", 41 Ethnikis Aminis Str., GR-54635 Thessaloniki, Greece.
Background/objectives: Feeding and eating disorders (FEDs) constitute an important mental health problem today, especially among youngsters. The Sick, Control, One, Fat, Food (SCOFF) questionnaire was developed 25 years ago and remains the most frequently applied screening tool for FEDs among adults and youngsters. The aim of the present study was to translate and adapt the SCOFF questionnaire to the Greek language, using a tertiary-setting adolescent sample.
View Article and Find Full Text PDFRelative Energy Deficiency in Sport-Multidisciplinary Treatment in Clinical Practice.
Nutrients
January 2025
Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, 72076 Tübingen, Germany.
Background/objectives: The primary aim of this study was to characterize athletes approaching an outpatient interdisciplinary and multidisciplinary consultation structure for athletes with a suspected relative energy deficiency in sport (REDs) cross-sectionally and longitudinally to prove treatment efficacy.
Methods: Data of 58 athletes suspected of REDs were collected at the onset (t) and completion (t) of interdisciplinary and multidisciplinary REDs treatment (clinical practice) between January 2019 and December 2022. The data included extracted information from medical records, anthropometric characteristics, physical performance diagnostics, laboratory values, dietary records, and partially gynecological and psychosomatic diagnostics.
The Neural Correlates of Body Image Processing in Anorexia Nervosa and Bulimia Nervosa: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies.
Int J Environ Res Public Health
January 2025
School of Psychology, Bond University, Gold Coast, QLD 4226, Australia.
Body image concerns are key prognostic and pathogenic factors of anorexia nervosa (AN) and bulimia nervosa (BN). This study aimed to investigate the neural mechanisms underlying body image perception across its two domains of estimation and satisfaction in anorexia and bulimia patients and healthy controls (HC). Systematic searches were conducted across eight databases, including PubMed; Cochrane Library; Ovid; Google Scholar; Sage Journals; Scopus; PsycInfo; and ScienceDirect, from database inception until the 23rd of April 2023.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!