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Severe refractory colitis after intraperitoneal infusion of CEA-directed CAR T cells in patients with colorectal cancer.
Ther Adv Med Oncol
December 2024
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang Province 310003, China.
Chimeric antigen receptor T (CAR T) cells have shown their potential in hematological malignancies and the treatment of solid tumors, especially in metastases. However, CAR T-cell therapy may carry risks of inducing severe adverse effects, which are recognized as immune-related adverse events. Here, we report two cases of severe colitis presented with refractory bloody diarrhea, which were induced by carcinoembryonic antigen (CEA)-directed CAR T therapy in the treatment of metastatic colorectal adenocarcinoma.
View Article and Find Full Text PDFSevere Ectopic Adrenocorticotropic Hormone Syndrome Due to Pulmonary Carcinoid Tumor: A Case Report and Literature Review.
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Division of Endocrinology, Department of Medicine, Duke University, Durham, North Carolina.
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The Long-Term Outcomes of Inactive Pacemaker Lead Abandonment in Children and Dramatic Observation of Complications.
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December 2024
Department of Cardiology, Medical University of Lublin, Lublin, Poland.
Transvenous extraction of the leads in children is associated with a higher risk of serious complications, that is why it is reluctantly performed. Unfortunately, this conservative approach has been associated with secondary complications (tricuspid valve dysfunction and bilateral venous obstruction), adverse events during lead removal procedure and recanalization and stenting of chest veins. We present a case of a 27-year-old female with a pacemaker and insertion of two new leads on the opposite side of the chest leaving the old ones in place.
View Article and Find Full Text PDFImplantation Metastasis Following a Biopsy of Thalamic Germinoma: A Case Report.
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Neurosurgery, Jose R. Reyes Memorial Medical Center, Manila, PHL.
Germ cell tumors (GCTs) commonly develop in the pineal and suprasellar regions, with the most common GCTs being germinomas. In this report, a 22-year-old male presented with progressive right-sided weakness, and his imaging was consistent with a left thalamic high-grade glioma. A stereotactic biopsy was performed, revealing a germinoma, but radiation therapy was not done, and the patient was lost to follow-up.
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