[Hemangiopericytoma of the uterus].

Zentralbl Gynakol

Frauenklinik, Bezirkskrankenhauses Schwedt/Oder.

Published: June 1989

Uterine hemangiopericytoma is reported in a 49 years old woman. It is a very rare tumour. The treatment of choice is total hysterectomy with bilateral salpingo-oophorectomy. Uterine hemangiopericytoma are of low malignancy with favourable prognosis and do seldom recur.

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A 44-yr-old woman with menorrhagia and uterine fibroids underwent total laparoscopic hysterectomy, revealing several submucosal, intramural, and subserosal tan-white nodules in the uterus. Microscopic examination revealed tumors displaying 3 distinct morphologies: 1 tumor with features of conventional leiomyoma; 1 tumor with increased cellularity, staghorn/hemangiopericytoma-like vasculature, and occasional atypical cells with prominent red nucleoli and some perinucleolar halos suggesting a fumarate hydratase (FH)-deficient atypical leiomyoma; and 1 tumor with an admixture of epithelioid and spindled cells with the former arranged around blood vessels suggesting a perivascular epithelioid cell tumor (PEComa). Immunohistochemical studies confirmed these diagnoses by demonstrating loss of FH expression in the atypical leiomyoma and diffuse expression of HMB45 and cathepsin K in the tumor with epithelioid features.

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