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The Influence of Fluoxetine on the Sensorimotor Function of the Sciatic Nerve in Wistar Rats after Axonotmesis: An Experimental Animal Model.
J Oral Maxillofac Surg
December 2024
PhD Adjunct Professor, in Oral and Maxillofacial Surgery, School of Dentistry, University of Pernambuco - UPE, Recife, Pernambuco, Brazil. Electronic address:
Background: Fluoxetine, a serotonin reuptake inhibitor antidepressant, raises extracellular serotonin levels and promotes angiogenesis and neurogenesis. Numerous animal models have shown its beneficial effects on recovery from peripheral nerve injury.
Purpose: The primary objective of this study was to analyze the influence of fluoxetine on the sensory-motor function recovery of the sciatic nerve in Wistar rats after axonotmesis.
Amelioration of Gap Junction Dysfunction in a Depression Model by Loganin: Involvement of GSK-3β/β-Catenin Signaling.
J Ethnopharmacol
December 2024
School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address:
Ethnopharmacological Relevance: Comus officinalis Sieb. et Zucc has significant neuroprotective activity and has been widely studied for its potential to improve cognitive function. Our team's previous research has found that loganin isolated from Comus officinalis has an antidepressant effect.
View Article and Find Full Text PDFCan fluoxetine influence orthodontic tooth movement? A systematic review and meta-analysis of studies on animal models.
Int Orthod
December 2024
Department of Periodontics and Endodontics, School of Dental Medicine, Stony Brook University, Stony Brook, NY, 11794, United States.
Introduction: Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine adversely affect bone mineral density (BMD) and turnover, thereby increasing the risk of fractures. The objective of the present systematic review and meta-analysis was to evaluate studies on animal models that assessed whether fluoxetine can influence orthodontic tooth movement (OTM).
Material And Methods: Indexed databases (PubMed/Medline, EMBASE, Cochrane Library, Scopus and ISI Web of Knowledge) and Google Scholar were searched without time and language barriers up to and including June 2024.
An Experimental Study to Evaluate the Antidepressant Effect of Zileuton and Aqueous Extract of Phyllanthus emblica in Unpredictable Chronic Mild Stress-Induced Depression in Albino Mice.
Cureus
November 2024
Pharmacology and Therapeutics, Seth Gordhandas Sunderdas Medical College and King Edward Memorial (KEM) Hospital, Mumbai, IND.
Introduction: Oxidative stress and proinflammatory signaling in the brain have been found to have a significant role in the pathogenesis of depression. Therefore, drugs that reduce oxidative stress and neuroinflammation may be helpful in depression as monotherapy or as an adjunct to conventional antidepressants. Zileuton, a 5-lipoxygenase inhibitor, has been identified as a putative antidepressant in an in vitro study.
View Article and Find Full Text PDFVilazodone, a Novel SSRI Antidepressant with 5-HT1A Partial Agonist Properties: Diminished Potentiation of Chronic Oral Methylphenidate-Induced Dynorphin Expression in the Striatum in Adolescent Male Rats.
Mol Neurobiol
October 2024
Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Selective serotonin reuptake inhibitor (SSRI) antidepressants such as fluoxetine are used in combination with the medical psychostimulant methylphenidate (Ritalin) in a variety of treatments in children and adults. Unintended co-exposure to these psychotropic medications also occurs in patients on SSRIs who abuse methylphenidate as a "cognitive enhancer" or recreational drug. Preclinical research shows that SSRIs such as fluoxetine when given in conjunction with methylphenidate potentiate addiction-related gene regulation by methylphenidate in the striatum, consistent with the known facilitatory role for serotonin in psychostimulant-induced neuronal and behavioral changes.
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