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Expression levels of IL-17 and TNF-α in degenerated lumbar intervertebral discs and their correlation. | LitMetric

AI Article Synopsis

  • The study focused on understanding the roles of interleukin-17 (IL-17) and tumor necrosis factor-alpha (TNF-α) in intervertebral disc degeneration (IDD) to help develop alternative therapies.
  • It involved analyzing 40 samples of nucleus pulposus tissue from patients with IDD, distinguishing between those with ruptured and intact annulus fibrosus, and comparing them to a control group with traumatic lumbar disc fractures.
  • Results showed that both IL-17 and TNF-α levels were significantly higher in IDD samples, especially in the ruptured annulus group, indicating their potential involvement and synergistic effects in the progression of IDD.

Article Abstract

The present study aimed to investigate the expression and roles of interleukin (IL)-17 and tumor necrosis factor (TNF)-α in intervertebral disc degeneration (IDD) and to identify the association between the effects of IL-17 and TNF-α in IDD. This may increase understanding of the pathogenic mechanism underlying IDD, and aid the development of alternative therapies. The experimental group consisted of 40 samples of nucleus pulposus tissue obtained from the intervertebral discs (IVDs) of patients with IDD by surgical intervention, and was further divided into an annulus fibrosus disrupted group, comprising 18 patients in which the external annulus was ruptured, and an annulus fibrosus intact group comprising 22 patients. The control group consisted of 20 samples of nucleus pulposus tissue from the IVDs of patients with traumatic lumbar disc fractures. The mRNA and protein expression levels of IL-17 and TNF-α in the 50 tissue samples were detected by semi-quantitative reverse transcription polymerase chain reaction and immunohistochemical staining, respectively, and the results were statistically analyzed. The IL-17 and TNF-α protein and mRNA expression levels in the annulus fibrosus disrupted and annulus fibrosus intact groups were both higher compared with those in the control group. In addition, the expression levels of IL-17 and TNF-α in the annulus fibrosus disrupted group were significantly higher compared with those in the annulus fibrosus intact group (P<0.01). A positive correlation was identified between the mRNA and protein expression levels of IL-17 and TNF-α in the experimental group (r=0.957, P<0.01). IL-17 and TNF-α may therefore be involved in the progression of human IDD, and may have synergistic effects in the development of IDD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887958PMC
http://dx.doi.org/10.3892/etm.2016.3250DOI Listing

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