AI Article Synopsis
- Recent advancements have led to the development of lymphatic reporter mouse lines that enhance imaging of lymphatic vessels.
- This study introduces a new Prox1-tdTomato transgenic mouse line, allowing researchers to directly visualize lymphatic vessels for better assessment of various conditions.
- Additionally, embryonic stem cells from this line were differentiated into lymphatic vessels in vivo, providing valuable tools for lymphatic research.
Article Abstract
Several lymphatic reporter mouse lines have recently been developed to significantly improve imaging of lymphatic vessels. Nonetheless, the usage of direct visualization of lymphatic vessels has not been fully explored and documented. Here, we characterized a new Prox1-tdTomato transgenic lymphatic reporter mouse line, and demonstrated how this animal tool enables the researchers to efficiently assess developmental, surgical and pathological lymphangiogenesis by direct visualization of lymphatic vessels. Moreover, we have derived embryonic stem cells from this reporter line, and successfully differentiated them into lymphatic vessels in vivo. In conclusion, these experimental tools and techniques will help advance lymphatic research.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900649 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157126 | PLOS |
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