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Obesity epidemic and prevailing standards of desired body shape encourage society to use weight loss aids. Thermogenics, which are dietary supplements aimed at increasing energy expenditure, are particularly gaining popularity. These preparations can be easily purchased without prescription and have a complex composition, which means they can interact with numerous substances.
View Article and Find Full Text PDFNorepinephrine mediates heart block during severe hypoglycemia in male rats.
Physiol Rep
August 2024
Division of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Hypoglycemia is common in people with type 1 diabetes. Sometimes, severe hypoglycemia can be fatal. The underlying mechanisms by which severe hypoglycemia can lead to death are unclear.
View Article and Find Full Text PDFM-currents (Kv7.2-7.3/KCNQ2-KCNQ3) Are Responsible for Dysfunctional Autonomic Control in Hypertensive Rats.
Front Physiol
November 2016
Division of Physiology, Department of Molecular Medicine, Institute for Basic Medical Sciences, University of Oslo Oslo, Norway.
Unlabelled: Autonomic dysfunctions play important roles in hypertension, heart failure and arrhythmia, often with a detrimental and fatal effect. The present study analyzed if these dysfunctions involved M-channels (members of the Kv7/KNCQ family) in spontaneously hypertensive rats (SHR). Cardiac output and heart rate (HR) were recorded by a flow probe on the ascending aorta in anesthetized SHR and normotensive rats (WKY), and blood pressure (BP) by a femoral artery catheter.
View Article and Find Full Text PDFNatural products as potential human ether-a-go-go-related gene channel inhibitors - screening of plant-derived alkaloids.
Planta Med
June 2014
Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland.
Article Synopsis
- * A study examined 32 plant-derived alkaloids and two semi-synthetic compounds, using an automated assay to assess their effects on the hERG channel.
- * Several alkaloids, including protopine and reserpine, were found to significantly reduce hERG current by at least 50%, indicating a potential toxicity risk associated with these common plant compounds.
Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders.
Am J Geriatr Pharmacother
August 2010
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Background: Few drugs are available for the management of hyperkinetic movement disorders such as the dystonias, choreas, dyskinesias, and tics. Those that are available (primarily neuroleptics) are associated with a wide range of potentially serious adverse effects, including induction of tardive movement disorders. Tetrabenazine (TBZ) is a monoamine-depleting agent initially studied in the 1950s and currently approved by the US Food and Drug Administration for the treatment of chorea in Huntington's disease.
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