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The concept of natural genome reconstruction.Part 1. Basic provisions of the "natural genome reconstruction" concept. Changing the genome of hematopoietic stem cells using several natural cellular mechanisms that are inherent in the hematopoietic cell and determine its biological status as "the source of the body's reparative potential".
Vavilovskii Zhurnal Genet Selektsii
November 2024
Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
We present a series of articles proving the existence of a previously unknown mechanism of interaction between hematopoietic stem cells and extracellular double-stranded DNA (and, in particular, double-stranded DNA of the peripheral bloodstream), which explains the possibility of emergence and fixation of genetic information contained in double-stranded DNA of extracellular origin in hematopoietic stem cells. The concept of the possibility of stochastic or targeted changes in the genome of hematopoietic stem cells is formulated based on the discovery of new, previously unknown biological properties of poorly differentiated hematopoietic precursors. The main provisions of the concept are as follows.
View Article and Find Full Text PDFPreserving positivity in density-explicit field-theoretic simulations.
J Chem Phys
December 2024
Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA.
Field-theoretic simulations are numerical methods for polymer field theory, which include fluctuation corrections beyond the mean-field level, successfully capturing various mesoscopic phenomena. Most field-theoretic simulations of polymeric fluids use the auxiliary field (AF) theory framework, which employs Hubbard-Stratonovich transformations for the particle-to-field conversion. Nonetheless, the Hubbard-Stratonovich transformation imposes significant limitations on the functional form of the non-bonded potentials.
View Article and Find Full Text PDFCombined stochastic modelling of pathogenic and spoilage microorganisms.
EFSA J
December 2024
Laboratory of Food Microbiology and Hygiene, Department of Food Science and Technology, School of Agriculture, Faculty of Agriculture, Forestry and Natural Environment Aristotle University of Thessaloniki Thessaloniki Greece.
Quantitative microbiological risk assessment (QMRA) of pathogens in food safety is well established, but steps are being taken to expand this methodology to food spoilage. Parallels can be drawn between the steps involved in a QMRA for pathogens and its application to specific spoilage organisms (SSO). During hazard characterisation for pathogens, the appropriate dose-response model is used to link the hazard level to the health outcome by estimating the probability of illness, resulting from the ingestion of a certain dose of the hazard.
View Article and Find Full Text PDFThe role of uncertain reward in voluntary task-switching as revealed by pupillometry and gaze.
Behav Brain Res
December 2024
Department of Psychological & Brain Sciences, Texas A&M University, Psychology Building, Building 0463, 515 Coke St, College Station, TX 77843, United States of America; Texas A&M Institute for Neuroscience, Texas A&M University, Interdisciplinary Life Sciences Building (ILSB), Room 3148 | 3474 TAMU, College Station, TX 77843-3474, United States of America. Electronic address:
Cognitive flexibility, the brain's ability to adjust to changes in the environment, is a critical component of executive functioning. Previous literature shows a robust relationship between reward dynamics and flexibility: flexibility is highest when reward changes, while flexibility decreases when reward remains stable. The purpose of this study was to examine the role of uncertain reward in a voluntary task switching paradigm on behavior, pupillometry, and eye gaze.
View Article and Find Full Text PDFEquipartitioning of Molecular Degrees of Freedom in MD Simulations of Gaseous Systems via an Advanced Thermostatization Strategy.
J Chem Theory Comput
December 2024
Theoretical Chemistry Division, Institute of General, Inorganic and Theoretical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
This work introduces a dedicated thermostatization strategy for molecular dynamics simulations of gaseous systems. The proposed thermostat is based on the stochastic canonical velocity rescaling approach by Bussi and co-workers and is capable of ensuring an equal distribution of the kinetic energy among the translational, rotational, and vibrational degrees of freedom. The outlined framework ensures the correct treatment of the kinetic energy in gaseous systems, which is typically not the case in standard approaches due to the limited number of collisions between particles associated with a large free mean path.
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