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Human Leukocyte Antigen Genotype as a Marker of Multiple Sclerosis Prognosis.
Can J Neurol Sci
March 2020
Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Objective: In a previous pilot monocentric study, we investigated the relation between human leukocyte antigen (HLA) genotype and multiple sclerosis (MS) disease progression over 2 years. HLA-A*02 allele was correlated with better outcomes, whereas HLA-B*07 and HLA-B*44 were correlated with worse outcomes. The objective of this extension study was to further investigate the possible association of HLA genotype with disease status and progression in MS as measured by sensitive and complex clinical and imaging parameters.
View Article and Find Full Text PDFHLA-B, HLA-C and KIR improve the predictive value of IFNL3 for Hepatitis C spontaneous clearance.
Sci Rep
January 2018
Infectious Diseases Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain.
IFNL3 is the strongest predictor of spontaneous resolution (SR) of hepatitis C virus (HCV), however, consideration of IFNL3 genotype alone is of limited clinical value for the prediction of SR or chronic HCV infection. The objective of this study was to analyze the impact of HLA-B, HLA-C and KIRs on SR, as well as their additive effects on the predictive value of the IFNL3 genotype. We conducted a retrospective study of HIV patients that included both SR and chronic HCV patients.
View Article and Find Full Text PDFHLA-B*44 May Be a Marker for Orofacial Granulomatosis.
J Pediatr Gastroenterol Nutr
November 2016
*Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital †Department of Otorhinolaryngology ‡Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki §Department of Pediatrics, Tampere University Hospital, University of Tampere, Tampere, Finland.
Clinical characteristics of Japanese patients with axial spondyloarthritis, and short-term efficacy of adalimumab.
J Orthop Sci
November 2015
Department of Orthopaedic Surgery, Fujita Health University, 1-98, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Background: Ankylosing spondylitis (AS) is rarer in Japan than in Europe, probably because the European criteria, not well known by Japanese general physicians, regard AS as a progressive stage of axial spondyloarthritis (SpA). HLA-B27 is an important diagnostic marker of SpA; however, the incidence of the HLA-B27 allele is as low as 0.4 % in Japan.
View Article and Find Full Text PDFSerological markers of erosive hand osteoarthritis.
Eur J Intern Med
January 2013
Rheumatology Unit, Department of Medicine DIMED, University of Padova, Italy.
This review focuses on biomarkers in erosive hand osteoarthritis (EHOA), a subset of hand osteoarthritis (HOA), that primarily affects interphalangeal joints and is characterized by abrupt onset, severe pain and functional impairment, as well as signs of inflammation, in particular stiffness, swelling, erythema, paraesthesiae, and worse outcome. Inflammatory features and radiographic erosions are the main diagnostic hallmarks of this particular disease subset. As in other fields of OA, EHOA biomarkers can be classified as dry and soluble.
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