AI Article Synopsis
- * Pregnant rats were treated with either control substances or zinc sulfate (ZnSO), which diminishes their sense of smell and thereby reduces licking behavior toward their pups.
- * Results showed that pups from ZnSO-treated mothers exhibited shorter LER durations and altered leg positions, indicating that reduced maternal licking negatively impacted the pups' reflex development, highlighting the importance of maternal care.
Article Abstract
This study examined the effect of maternal behavior on the expression and postnatal development of a reflexive behavior in rat pups. In neonatal rats, the leg extension response (LER) is a bilateral hyperextension of the hindlimbs in response to maternal anogenital licking (AGL). Past research has found that intranasal application of zinc sulfate (ZnSO ) to the dam induces hyponosmia, thereby reducing the incidence of AGL. In this study, pregnant dams received intranasal application of air (control), distilled water (control), or ZnSO on the day before birth and every other day thereafter until postnatal day 9 (P9). The LER was experimentally evoked in pups, using a vibrotactile device, at P1, P5, or P10. Pups born to ZnSO -treated dams showed significantly shorter bilateral LER durations and significantly smaller ankle angles than pups born to control dams. Reduction of overall maternal AGL approached significance, and afternoon AGL was significantly reduced. These data suggest that maternal behavior influenced development of the LER in rat pups, demonstrating the influence of maternal care on behavioral development during the perinatal period.
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| http://dx.doi.org/10.1002/dev.21438 | DOI Listing |
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