AI Article Synopsis
- The study aimed to evaluate how effective Sonazoid-enhanced ultrasonography (US) is for diagnosing ovarian cancer compared to traditional Doppler US.
- Twenty-five patients with ovarian tumors were assessed using different ultrasound techniques before surgery, and their tumors were classified as benign or malignant based on various criteria.
- Results showed that Sonazoid-enhanced US had a 92% accuracy in detecting blood flow in tumors, outperforming color Doppler (64% accuracy) but not power Doppler (76% accuracy); however, caution is advised due to the small sample size and further research is needed.
Article Abstract
Purpose: The purpose of this study was to assess the usefulness of Sonazoid(®)-enhanced ultrasonography (US) in the diagnosis of ovarian cancer in comparison with Doppler US.
Methods: Twenty-five ovarian tumor patients who were scheduled to undergo surgery were recruited for this study. The day before the operation, each patient was evaluated with color and power Doppler and baseline US during intravenous infusion of Sonazoid. Each lesion was classified as "benign" or "malignant" on the basis of specific criteria for a Doppler signal or Sonazoid-enhanced pattern. The reference standard was the histology of surgically removed adnexal tumors.
Results: Twenty patients were diagnosed with malignant tumors (invasive cancer, n = 15; metastatic cancer, n = 1; borderline tumor, n = 4), and the remaining five were diagnosed with benign tumors. Sonazoid-enhanced US correctly depicted the presence or absence of intratumoral blood flow in all patients with an accuracy of 92 %. Color Doppler ultrasound depicted the malignancies with an accuracy of 64 %, and power Doppler ultrasound depicted them with an accuracy of 76 %.
Conclusion: Our study suggests that Sonazoid-enhanced US is superior to conventional color Doppler US for the diagnosis of malignant ovarian tumors, but not to power Doppler US. The data and their interpretation in our study should be taken with some degree of caution because of the small number of subjects. Further studies involving a larger sample size would be needed to confirm these findings.
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| http://dx.doi.org/10.1007/s10396-012-0380-9 | DOI Listing |
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