Neonatal lupus erythematous (NLE) is a rare autoimmune disease caused by placental transfer of maternal anti-SSA/Ro or anti-SSB/La antibodies. It usually presents with transient cutaneous lesions, congenital heart block and other systemic symptoms. The authors report a case of neonatal lupus erythematosus who presented with targetoid-like lesions on both feet.
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Neonatal lupus erythematosus: 24 years of experience from a tertiary centre at Chandigarh, North India.
Lupus
January 2025
Allergy Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Objective: To study the clinical features and laboratory parameters of neonatal lupus erythematosus (NLE) from India.
Patients And Methods: We analyzed case records of children diagnosed with NLE in the Pediatric Rheumatology Clinic at tertiary care centre from North India during the period January 1999 - December 2023.
Results: Twenty-four babies are diagnosed with NLE during the study period.
Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review.
Front Pediatr
October 2024
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Introduction: There are few reports of severe hematological involvement in children with neonatal lupus erythematosus (NLE) treated with exchange transfusion. In this case report, we present a female patient with NLE admitted to the Children's Hospital of Soochow University. The main clinical manifestations were pancytopenia and congenital heart block (CHB).
View Article and Find Full Text PDFFetal-hope study: Home monitoring of fetal heart rate in SSA + pregnant women: Rationale and design.
Eur J Obstet Gynecol Reprod Biol
December 2024
Department of Internal Medicine, ASST Fatebenefratelli-Sacco, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Italy.
Article Synopsis
- About 0.5-1% of women of childbearing age have anti-Ro/SSA and anti-La/SSB antibodies, potentially leading to Neonatal Lupus, primarily manifesting as complete heart block (AVB) in fetuses.
- The study aims to assess the effectiveness of home monitoring of fetal heart rates using a handheld device in pregnant women with these antibodies and to see if early treatment can help.
- Currently, patients are being recruited across 11 Italian centers for a prospective observational study, with regular monitoring and check-ups to track maternal and fetal health outcomes.
A clinical image of cutaneous neonatal lupus erythematosus.
J Paediatr Child Health
November 2024
Department of Paediatrics, Era's Lucknow Medical College & Hospital, Lucknow, India.
Neonatal lupus erythematosus presenting as raccoon eyes.
Indian J Dermatol Venereol Leprol
September 2024
Department of Dermatology, Yenepoya Medical College Hospital, Derlakatte, Mangalore, India.
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