Heightened cutaneous immune surveillance in atopic patients may inhibit development of melanoma. The aim of this study was to analyse the association between atopy and melanoma (development and outcome). A total of 188 cases of melanoma and 596 healthy controls were interviewed by telephone with a standardized questionnaire on atopic, demographic and melanoma characteristics. Cases were matched with controls on important confounders (age, sex, sunburn sensitivity, hair colour, number of moles, sunburn as juvenile, ever solarium, familial melanoma). Melanoma outcome data (disease relapse and death) within cases were retrieved. Analysis showed a general inverse association between atopy and melanoma development, but this was statistically significant only for a history of personal atopy (odds ratio 0.53, 95% confidence interval: 0.30-0.96, p-value = 0.04). Among melanoma patients, atopy did not affect survival or progression. In conclusion, this study suggests an inverse association between a history of atopy and melanoma development, but not with disease progression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2340/00015555-2476 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Atopy improves survival and decreases risk of brain metastasis in cutaneous melanoma.
medRxiv
May 2024
Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Article Synopsis
- New therapies for melanoma have improved patient survival rates, leading to more cases of brain metastasis (BrM) developing, making it crucial to identify at-risk patients.
- This study aimed to investigate if a history of atopy (allergic conditions) affects survival rates or the incidence of BrM in older patients with cutaneous melanoma.
- The findings revealed that individuals with atopy had a 16% lower risk of death and a 15% decreased likelihood of developing BrM, particularly noting that those with atopic dermatitis experienced a 25% reduction in risk.
Patients with a history of atopy have fewer cutaneous melanomas than those without atopy: a cross-sectional study in 496 patients at risk of skin cancers.
Melanoma Res
June 2023
Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
The connection between atopy and skin cancers may be related to the stimulation of protective immune response, for example, through autoreactive immunoglobulin-E (IgE), or to the predisposition to carcinogenesis through chronic inflammation. The aim of this study was to investigate whether a past or present atopic disorder is associated with cutaneous photodamage, pigment cell nevi and skin cancers. For this, adult subjects at risk of any type of skin cancer (aged 21-79 years, 250 males, 246 females, 94 with immunosuppression) were examined for past or present malignancies in skin and extracutaneous site (ECS), photodamage, nevi, past or present atopic disorder in skin or mucus membranes, and possible other cancer-related factors.
View Article and Find Full Text PDFRisk Factors for Actinic Keratoses: A Systematic Review and Meta-Analysis.
Indian J Dermatol
January 2022
Department of Dermatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, District Baiyun, Guangzhou, Guangdong, China.
Objective: To integrate evidence and assess the risk factors associated with actinic keratosis (AK).
Methods: Unrestricted searches were conducted on five electronic databases, with an end-date parameter of September 2021. We summarized the study characteristics and pooled the results from individual studies by using a random-effects model.
Opposing Roles of Antimicrobial Peptides in Skin Cancers.
Curr Pharm Des
March 2022
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo,Japan.
Antimicrobial peptides (AMPs), also known as host defense peptides, are ubiquitous naturally occurring molecules secreted by various cell types of the body. In the skin, AMPs serve as a first-line innate immune defense against exogenous microorganisms, and they orchestrate adaptive immune responses to exert several immunomodulatory functions. Emerging evidence indicates that AMPs not only contribute to certain inflammatory skin diseases but also play a role in skin tumor carcinogenesis.
View Article and Find Full Text PDFMelanocyte progenitor cells reside in human subcutaneous adipose tissue.
PLoS One
December 2021
Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Based on the assumption that some progenitor cells in an organ might reside in neighboring adipose tissue, we investigated whether melanocyte progenitor cells reside in human subcutaneous adipose tissue. First, we examined the expression of human melanoma black 45 (HMB45) and microphthalmia-associated transcription factor (MITF) in undifferentiated adipose-derived stem cells (ADSCs) by immunostaining, RT-PCR, and western blotting. These two markers were detected in undifferentiated ADSCs, and their expression levels were increased in differentiated ADSCs in melanocyte-specific culture medium.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!