AI Article Synopsis
- Stem cells and therapeutic cells like T cells show potential for curing previously untreatable diseases, shifting the focus of modern medicine toward cell-based therapies.
- For this shift to succeed, we need advancements in manufacturing technologies that ensure large-scale, cost-effective, and consistent production of high-quality therapeutic cells.
- The review highlights the current state of therapeutic cell manufacturing processes and addresses challenges while proposing solutions for making cell therapies safer, more effective, and accessible.
Article Abstract
Stem cells and other functionally defined therapeutic cells (e.g., T cells) are promising to bring hope of a permanent cure for diseases and disorders that currently cannot be cured by conventional drugs or biological molecules. This paradigm shift in modern medicine of using cells as novel therapeutics can be realized only if suitable manufacturing technologies for large-scale, cost-effective, reproducible production of high-quality cells can be developed. Here we review the state of the art in therapeutic cell manufacturing, including cell purification and isolation, activation and differentiation, genetic modification, expansion, packaging, and preservation. We identify current challenges and discuss opportunities to overcome them such that cell therapies become highly effective, safe, and predictively reproducible while at the same time becoming affordable and widely available.
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| http://dx.doi.org/10.1146/annurev-chembioeng-080615-033559 | DOI Listing |
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