In this issue of Structure, Lambert et al. (2016) describe extensive structural and functional work on meganucleases, the group of homing endonucleases most commonly adapted to genome engineering applications. The data are of interest to structural biologists, evolutionary biologists, protein designers, and genome engineers.
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| http://dx.doi.org/10.1016/j.str.2016.05.008 | DOI Listing |
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WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium.
Front Microbiol
December 2024
Scientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Introduction: WhiA is a conserved protein found in numerous bacteria. It consists of an HTH DNA-binding domain linked with a homing endonuclease (HEN) domain. WhiA is one of the most conserved transcription factors in reduced bacteria of the class Mollicutes.
View Article and Find Full Text PDFComplete genomes of Asgard archaea reveal diverse integrated and mobile genetic elements.
Genome Res
October 2024
Innovative Genomics Institute, University of California, Berkeley, California 94720, USA;
Article Synopsis
- Asgard archaea, key ancestors of Eukaryotes, have mobile genetic elements (MGEs) that are not well understood, and this study investigates two complete genomes from the Atabeyarchaeia lineage to explore these elements.
- The research identifies 18 MGEs in Atabeyarchaeia, including a notable 20.67 kbp circular plasmid and specific viruses that might influence their evolution through gene interactions.
- Differences in defense mechanisms, such as restriction-modification systems, between Atabeyarchaeia and another Asgard archaea, Freyarchaeia, highlight how these systems can affect the relationship with MGEs and contribute to genetic diversity in these organisms.*
EsxA, a type VII secretion system-dependent effector, reveals a novel function in the sporulation of Bacillus cereus ATCC14579.
BMC Microbiol
September 2024
Division of Infection and Immunity, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Background: Bacillus cereus is a Gram-positive, spore-forming bacterium that produces a spectrum of effectors integral to bacterial niche adaptation and the development of various infections. Among those is EsxA, whose secretion depends on the EssC component of the type VII secretion system (T7SS). EsxA's roles within the bacterial cell are poorly understood, although postulations indicate that it may be involved in sporulation.
View Article and Find Full Text PDFComplete mitochondrial genome sequence of the white root rot pathogen (Xylariaceae: Xylariales).
Mitochondrial DNA B Resour
September 2024
Hans Merensky Chair in Avocado Research, Forestry and Agricultural Biotechnology Institute (FABI), University of Pretoria, Pretoria, South Africa.
The mitochondrial genome of is 121,350 base pairs in length with a G + C content of 30.19%. Phylogenetic analysis showed that grouped with other members of the Xylariaceae, with which its mitogenome also shares a broadly similar architecture and gene content.
View Article and Find Full Text PDFExploring Mitochondrial Heterogeneity and Evolutionary Dynamics in through Population Genomics.
Int J Mol Sci
August 2024
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650032, China.
Limited exploration in fungal mitochondrial genetics has uncovered diverse inheritance modes. The mitochondrial genomes are inherited uniparentally in the majority of sexual eukaryotes, our discovery of persistent mitochondrial heterogeneity within the natural population of the basidiomycete fungus represents a significant advance in understanding mitochondrial inheritance and evolution in eukaryotes. Here, we present a comprehensive analysis by sequencing and assembling the complete mitogenomes of 40 samples exhibiting diverse heterogeneity patterns from various geographical origins.
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