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Assessment of ICG fluorescence in identification and preservation of parathyroid glands in thyroid surgeries and correlation with postoperative parathormone and serum calcium levels.
Endocrine
January 2025
Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Introduction: Intraoperative parathyroid gland (PG) localization remains challenging during thyroid surgeries, contributing to postoperative hypocalcemia and hypoparathyroidism. This study assessed the efficacy of indocyanine green (ICG) fluorescence in identifying and preserving PGs during thyroid surgeries and its correlation with postoperative outcomes.
Materials And Methods: This ambispective observational study included 57 patients undergoing thyroid surgeries using ICG and compared outcomes with 56 historical controls.
Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations.
Ann Hum Genet
January 2025
Institute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Introduction: Southern Africa has been inhabited by hunter-gatherers for at least 20,000 years and has received diverse immigration flows in the last 2000 years. The original inhabitants have interacted with the pastoralist migrants from Eastern Africa (∼2000 ybp), followed by the southern Bantu migration arriving some 1000 ybp, and more recently with the European and Asian settlers after the 17th century. Many of the original Khoekhoe and San inhabitants have either become extinct or have disappeared through admixture in South Africa (SA), in a sex-biased manner involving KhoeSan women.
View Article and Find Full Text PDFTargeted Covalent Modification Strategies for Drugging the Undruggable Targets.
Chem Rev
January 2025
Graduate School of Engineering, Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
The term "undruggable" refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Drugging such undruggable targets is essential to develop new therapies for diseases where current treatment options are limited or nonexistent. Thus, investigating methods to achieve such drugging is an important challenge in medicinal chemistry.
View Article and Find Full Text PDFEnhance the Concrete Crack Classification Based on a Novel Multi-Stage YOLOV10-ViT Framework.
Sensors (Basel)
December 2024
College of Automation and College of Artificial Intelligence, Nanjing University of Posts and Telecommunications, Nanjing 210046, China.
Early identification of concrete cracks and multi-class detection can help to avoid future deformation or collapse in concrete structures. Available traditional detection and methodologies require enormous effort and time. To overcome such difficulties, current vision-based deep learning models can effectively detect and classify various concrete cracks.
View Article and Find Full Text PDFIdentification of Neonatal Factors Predicting Pre-Discharge Mortality in Extremely Preterm or Extremely Low Birth Weight Infants: A Historical Cohort Study.
Children (Basel)
November 2024
Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Background/objectives: This study identified early neonatal factors predicting pre-discharge mortality among extremely preterm infants (EPIs) or extremely low birth weight infants (ELBWIs) in China, where data are scarce.
Methods: We conducted a retrospective analysis of 211 (92 deaths) neonates born <28 weeks of gestation or with a birth weight <1000 g, admitted to University Affiliated Hospitals from 2013 to 2024 in Guangzhou, China. Data on 26 neonatal factors before the first 24 h of life and pre-discharge mortality were collected.
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