Although laboratory studies started about twenty years ago, the international interest in transplants for Parkinson's disease was not aroused until the 1980's. Since the spectacular report by Madrazo et al. (1987), several groups of research-workers in various parts of the world are trying to reproduce or surpass these results. The latest studies indicate that while patients draw some benefits from adrenal medullary transplant to caudate nucleus, the operation involves inordinary risks. Moreover, the efficacy of this method is clearly less impressive now than was originally reported.
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