Background: The rate of obesity is increasing throughout the world. Obesity in adults' research is characterized by chronic inflammation, associated with type 2 Diabetes and cardiovascular risk. The degree to which these changes occur in childhood obesity is not fully defined.
Aim: This study was designed to explore the relation between circulating levels of pro-inflammatory cytokines, and obesity.
Patients And Methods: This cross sectional case control study was carried out in 50 randomly selected pre-pubertal overweight and obese children compared with fifty apparently healthy children of matched age and sex. Serum levels of transforming growth factor-β1, interleukin-6, and haptoglobin were quantified by ELISA technique.
Results: ANOVA test followed by Post Hoc test showed highly significant increase in the serum levels of the transforming growth factor-β1, interleukin-6 and haptoglobin among obese children compared to overweight and healthy children respectively. The body weight, BMI and BMI z-score were significantly positively correlated with serum levels of the three pro-inflammatory cytokines. Serum levels of interleukin-6, and haptoglobin were found to be strong predictors of complications in severe obesity by linear regression analysis.
Conclusions: Obesity is associated with chronic low-grade inflammation. High levels of interleukin-6 and haptoglobin are considered to be early biomarkers of inflammation associated with severe obesity with subsequent cardiovascular and type 2 diabetes risk.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877766 | PMC |
| http://dx.doi.org/10.3889/oamjms.2015.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Different Paths That Lead to Hypotonic Hyponatremia, and a Safe Approach to Treatment.
J Clin Med
December 2024
NYU Grossman Long Island School of Medicine, 101 Mineola Blvd., Mineola, NY 11501, USA.
A knowledge gap may exist when attempting to identify the pathogenetic mechanisms resulting in the syndrome of inappropriate antidiuretic hormone (SIADH) or hypotonic hyponatremia. Ectopic secretion of antidiuretic hormone [ADH] is the classic cause of SIADH. But another form of inappropriate secretion of ADH occurs when interleukin 6 is activated.
View Article and Find Full Text PDFInflammatory and Hemolytic Responses of Microaxial Flow Pump Temporary Ventricular Assist Devices via Axillary Access in Cardiogenic Shock.
Medicina (Kaunas)
November 2024
Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
The use of temporary left ventricular assist devices (tLVADs) for patients suffering from cardiogenic shock (CS) is becoming more common. This study examines the indications and outcomes of microaxial flow pumps (Impella, Abiomed Inc., Danvers, MA, USA) when cannulated through the axillary artery in patients with severe CS, with a particular focus on acute phase reactions and hemolytic responses.
View Article and Find Full Text PDFInvestigation of the diagnostic and prognostic importance of Tumor Necrosis Factor-alfa (TNF-α), Procalcitonin (PCT), Interleukin-6 (IL-6) and Haptoglobin (HP) in calves with neonatal diarrhea.
Vet Immunol Immunopathol
November 2024
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Erciyes University, Kayseri, Turkey.
Article Synopsis
- - This study examines how levels of Procalcitonin, Tumor Necrosis Factor-alpha, Interleukin-6, and Haptoglobin affect the survival outcomes of calves with diarrhea, categorizing them by severity and type of infection (viral, bacterial, parasitic).
- - A total of 48 diarrheic calves were divided into groups based on their infection type, with blood samples analyzed to track changes over time; the study found a 18.75% mortality rate, with the highest deaths in the severe viral group.
- - The results indicate that Procalcitonin levels can serve as a prognostic biomarker for diarrheic calves, aiding in assessing their conditions across different causes of diarrhea, emphasizing its
Serum markers of microbial translocation and intestinal damage in assessment of gastrointestinal tract involvement in systemic sclerosis.
Clin Exp Med
September 2024
Department of Translational and Precision Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Gastrointestinal (GI) tract involvement affects up to 90% of Systemic sclerosis (SSc) patients. The presence of GI symptoms is assessed by the University of California, Los Angeles, and Scleroderma Clinical Trials Consortium Gastrointestinal Scale (UCLA SCTC GIT 2.0).
View Article and Find Full Text PDFAssociations of Neonatal Dairy Calf Faecal Microbiota with Inflammatory Markers and Future Performance.
Animals (Basel)
August 2024
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, F. R. Kreutzwaldi 62, 51006 Tartu, Estonia.
After birth, the immune system is challenged by numerous elements of the extrauterine environment, reflected in fluctuations of inflammatory markers. The concentrations of these markers in the first month of life are associated with the future performance of dairy youngstock. It is thought that bacterial genera colonizing the calf intestinal tract can cause inflammation and thus affect their host's performance via immunomodulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!