Low-grade nasopharyngeal papillary adenocarcinoma is an extremely rare tumor, with only a limited number of cases reported in the literature. Some published studies have paid more attention to the clinicopathological features of nasopharyngeal adenocarcinoma, while little effort has been made to study the optimal therapeutic strategies. We report about a woman diagnosed with low-grade nasopharyngeal papillary adenocarcinoma. She received the treatment approach that combined transnasal endoscopic surgery to remove the lesion with postoperative radiotherapy for nasal cavity. There was no evidence of recurrence after 4 months of surgery, and further follow-up is being continued. Through this example, we wanted to explore the optimal therapeutic strategies for primary nasopharyngeal adenocarcinomas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876094PMC
http://dx.doi.org/10.2147/OTT.S100447DOI Listing

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Article Synopsis
  • Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is a rare cancer affecting the nasopharynx, with a study involving 35 patients revealing common symptoms like nasal obstruction and rhinorrhea, primarily in individuals aged 11 to 71.
  • Most tumors were T1N0M0 stage and exhibited irregular papillary structures, with various histopathological features, such as squamous differentiation in some cases and a significant spindle cell component in many.
  • Treatment typically involves endoscopic surgical resection, and follow-up showed no recurrence or metastasis in patients, supporting the idea that LGNPPA may be better categorized as a primary papillary epithelial tumor due to its slow-growing nature.
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