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Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model.
Toxicol Sci
January 2025
Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD, 21702, USA.
Because the liver plays a vital role in the clearance of exogenous chemical compounds, it is susceptible to chemical-induced toxicity. Animal-based testing is routinely used to assess the hepatotoxic potential of chemicals. While large-scale high-throughput sequencing data can indicate the genes affected by chemical exposures, we need system-level approaches to interpret these changes.
View Article and Find Full Text PDFMagnitude of telemedicine utilization and associated factors among health professionals working at selected public hospitals in Southern Ethiopia.
PLoS One
January 2025
School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia.
Background: Despite the immense potential of telemedicine, its implementation in Ethiopia and other developing nations has faced formidable challenges, leading to disappointingly low utilization rates. Therefore, this study sought to assess the magnitude and factors associated with telemedicine service practice among healthcare professionals in the pilot public hospitals of Sidama and Southern Nations Nationalities Peoples Regions.
Methods: Cross-sectional study was conducted from June 1-30, 2021 among randomly selected 407 health professionals working at Pilot Hospitals in Southern Ethiopia.
Perspectives on Half-Century of Combat Casualty Care in the Israel Defense Forces Medical Corps.
Isr Med Assoc J
November 2024
Surgeon General's Headquarters, Israel Defense Forces, Ramat Gan, Israel, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Background: Military medicine has evolved significantly over the past 50 years, advancing from basic treatments and limited evacuations to sophisticated combat casualty care. Innovations such as hemorrhage control, early blood product administration, and telemedicine have greatly improved battlefield care. Rapid evacuation systems and skilled medical teams have reduced mortality and morbidity rates.
View Article and Find Full Text PDFPrimary Care Practice Telehealth Use and Low-Value Care Services.
JAMA Netw Open
November 2024
Institute for Healthcare Policy and Innovation, Department of Urology, University of Michigan, Ann Arbor.
Importance: The rapid expansion of telehealth transformed how primary care practices deliver care; however, uncertainties about the quality of telehealth-delivered care compared with in-person care remain. While there are concerns that increased telehealth may introduce wasteful care, how telehealth affects the delivery of low-value care is unknown.
Objective: To examine whether a primary care practice's level of telehealth use is associated with changes in the rates of low-value care.
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