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Evaluation of a Physiologic-Driven Closed-Loop Resuscitation Algorithm in an Animal Model of Hemorrhagic Shock.
Crit Care Med
December 2024
Center for Military Medicine Research, University of Pittsburgh, Pittsburgh, PA.
Article Synopsis
- - The study aimed to evaluate a closed-loop resuscitation algorithm called ReFit1 and ReFit2, which uses various hemodynamic parameters to effectively manage severe hemorrhagic shock in a pig model.
- - The ReFit algorithm determines the need for fluids and medications based on real-time monitoring of vital signs, such as mean arterial pressure and mixed venous oxygen saturation, to drive automated treatments.
- - Results showed that the time to stabilize the pigs using these algorithms was comparable to traditional methods used by expert clinicians, with similar treatment volumes, and ReFit1 also successfully addressed complications like acute air embolism in some animals.
Single Center-Based Real-World Experience on Anti-IL 1 Biological Response Modifiers: A Case Series and Literature Review.
Children (Basel)
September 2024
Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Article Synopsis
- Anti-IL-1 biologics, particularly anakinra, are being explored for treating autoimmune and autoinflammatory conditions in children, highlighting their off-label use.
- Anakinra has shown effectiveness in personalized treatment approaches and for conditions like rheumatic fever and post-viral arthritis, while canakinumab has been linked to long-term remission.
- The authors call for increased collaboration to enhance access to these medications, aiming to better manage harmful inflammation in pediatric patients.
FreeClimb 88 catheter with Tenzing 8 delivery for contact aspiration mechanical thrombectomy of anterior circulation large vessel occlusions.
Interv Neuroradiol
September 2024
Neurointerventional Surgery, California Pacific Medical Center, San Francisco, CA, USA.
Article Synopsis
- The study evaluates the effectiveness of a new thrombus removal method called Contact Aspiration Mechanical Thrombectomy (CAMT) using specialized catheters (FreeClimb 88 and Tenzing 8) in treating large vessel occlusions in the brain.
- A retrospective analysis of 53 patients showed a high success rate for delivering the FreeClimb 88 catheter to the occlusion site, with 94.3% successful deliveries and a first-pass success rate of 67.9% for restoring blood flow.
- The procedure was found to be safe, with no complications or symptomatic hemorrhages, indicating that this technique could be a reliable option for treating these severe blockages.
A field-portable electrochemical immunosensor based on a multifunctional AgO/g-CN@MA-DBB covalent organic framework receptor interface for single-step detection of aflatoxin M in raw milk samples.
Nanoscale Adv
September 2024
Department of Chemistry, Govt College Women University Arfa Kareem Road Faisalabad 38000 Pakistan
Aflatoxin M (AFM), a hydroxylated metabolite of aflatoxin B (AFB), contaminates milk and dairy products from livestock ingestion of feed contaminated with a species of . As AFM is a Group-II B carcinogen, it is indispensable to develop novel, easy-to-handle, sensitive, portable and cost-effective strategies for its detection. Herein, a covalent organic framework (COF)-based electroactive nanocomposite, AgO/g-CN-COOH@MA-DBB-COF (silver oxide/carboxy-functionalized graphitic carbon nitride@melamine-dibromo butane COF), is designed to serve as a multifunctional receptor surface.
View Article and Find Full Text PDFUsing intervention mapping to facilitate and sustain return-to work after breast cancer: protocol for the FASTRACS multicentre randomized controlled trial.
BMC Cancer
September 2024
Research on Healthcare Performance RESHAPE, Université Claude Bernard Lyon 1, INSERM U1290, Lyon, France.
Background: Women with breast cancer face many barriers to return to work (RTW) after their cancer. The main objective of the FASTRACS-RCT is to evaluate the impact of the FASTRACS (Facilitate and Sustain Return to Work after Breast Cancer) intervention on the sustainable RTW of breast cancer patients, 12 months after the end of active treatment.
Methods: FASTRACS-RCT is a prospective, national, multicentre, randomized, controlled and open-label study.
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