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Screening for Hypoglycaemia Risk and Medication Changes in Diabetes Patients Using Pharmacy Dispensing Data.
J Clin Med
September 2024
Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, 9713 AV Groningen, The Netherlands.
: To improve hypoglycaemia management in primary care, more insight is needed into the opportunities to screen for hypoglycaemia risk and subsequent treatment modification using routinely available data. Our primary aim was to assess the number of diabetes patients with an estimated high risk of hypoglycaemia and describe the treatment changes in these patients using pharmacy dispensing data. Additionally, our aim was to investigate patient characteristics associated with such treatment changes.
View Article and Find Full Text PDFDigital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status.
Front Oncol
September 2024
Institute of Head and Neck Studies and Education, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Article Synopsis
- Oropharyngeal cancer (OPC) cases are rising, especially HPV-related ones, which generally have a better prognosis; however, the detection methods currently in use do not effectively differentiate between HPV-positive and HPV-negative cases, potentially leading to inappropriate treatment decisions.
- Researchers utilized GeoMx digital spatial profiling to analyze gene expression in three OPC subtypes (p16+/HPV+, p16+/HPV-, and p16-/HPV-) from tumor samples to uncover these discrepancies.
- The study found that certain genes associated with survival and proliferation were more active in p16-/HPV- tumors, while genes linked to immune response were elevated in p16+/HPV+ tumors, highlighting the need to further explore the implications of
Trends in the treatment of human papillomavirus-associated oropharyngeal carcinoma in Slovakia.
Neoplasma
August 2024
Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
The optimal treatment of oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) is currently a subject of clinical research. This questionnaire study investigated current trends in the treatment of HPV-associated (HPV+) OPC in Slovakia with the incorporation of deintensification of oncological treatment into routine clinical practice outside of clinical trials. The Slovak Cooperative Head and Neck Cancer Group (SCHNCG) developed a questionnaire aimed at identifying trends in the oncological treatment of HPV+ OPC intended for all radiation oncology (RO) facilities in Slovakia.
View Article and Find Full Text PDFAbandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes.
JAMA Oncol
February 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Surgery, Amsterdam, the Netherlands.
Importance: Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in 2014.
Objective: To determine the association of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall survival at a national level.
Common Instances of Low-value Care in Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol
May 2024
University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois.
Article Synopsis
- * The review highlights specific low-value care practices in diagnosing and monitoring inflammatory bowel diseases (IBD), such as over-relying on symptoms and unnecessary screenings.
- * It further discusses ineffective treatments and management strategies for hospitalized IBD patients, emphasizing the need for better evaluation and implementation of value-based care practices.
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