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Classifying crash causation patterns in 2-vehicle collisions between autonomous and conventional vehicles.
Traffic Inj Prev
January 2025
School of Traffic & Transportation Engineering, Changsha University of Science & Technology, Changsha, Hunan, China.
Objective: This study aims to investigate the causes of 2-vehicle collisions involving an autonomous vehicle (AV) and a conventional vehicle (CV). Prior research has primarily focused on the causes of crashes from the perspective of AVs, often neglecting the interactions with CVs.
Method: To address this limitation, the study proposes a classification framework for crash causation patterns in 2-vehicle collisions involving an AV and a CV, considering their interactions.
Limitation of site-stratified cox regression analysis in survival data: a cautionary tale of the PANAMO phase III randomized, controlled study in critically ill COVID-19 patients.
Trials
December 2024
School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI, USA.
Current guidelines tend to focus on a p-value threshold of a pre-specified primary endpoint tested in randomized controlled clinical trials to determine a treatment effect for a specific drug. However, a p-value does not always provide evidence on the treatment effect of a drug, especially when stratification of the data does not account for unforeseen variables introduced into the analysis. We report and discuss a rare case in which investigational site stratification in the pre-specified analysis method of a primary endpoint results in a loss of statistical power in the evaluation of the treatment effect due to data attrition of almost 17% of outcome data in the phase III randomized, controlled PANAMO study in critically ill COVID-19 patients.
View Article and Find Full Text PDFUnforeseen severity in a case of neonatal cow milk protein allergy: A case report.
J Pak Med Assoc
November 2024
Department of Paediatrics, Dr. Ziauddin Hospital, Karachi, Pakistan.
Article Synopsis
- Cow milk protein allergy (CMPA) is a common allergy in children, often showing digestive and skin symptoms that usually improve with age.
- A case of a one-month-old male with severe neonatal CMPA presented symptoms resembling a metabolic disorder and sepsis, leading to multiple hospital stays.
- The report emphasizes the importance of considering CMPA as a diagnosis in severe cases to prevent complications and reduce the need for prolonged hospitalizations in children.
Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E-selectin binding. However, these glycoepitopes lack cancer specificity, and E-selectin-targeted glycoproteins remain largely unknown. Here, we established a framework for identifying metastasis-linked glycoproteoforms.
View Article and Find Full Text PDFRetrospective analysis of survival and safety of bevacizumab biosimilar and original drug combination chemotherapy in non-small cell lung cancer.
Front Oncol
October 2024
Pharmacy Department, Baotou Cancer Hospital, Baotou, China.
Introduction: The advent of bevacizumab has considerably transformed the therapeutic landscape for non-small cell lung cancer (NSCLC) patients devoid of specific genetic mutations. A pivotal milestone has been reached with the recent approval of a bevacizumab biosimilar, following rigorous phase III clinical investigations, poised to augment NSCLC therapeutic strategies.
Methods: This retrospective analysis encompasses a large-scale study conducted between January 2021 and December 2023, involving 1058 NSCLC patients (metastatic or locally advanced stages).
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