AI Article Synopsis
- Developed an innovative apparatus that allows for repeated blood sampling in rats while they remain undisturbed, enabling concurrent activity assessment.
- The apparatus maintains stable body weights and ensures plasma hormone levels (corticosterone and prolactin) are comparable to those in free-ranging rats during a week-long experiment.
- This technique offers researchers a way to control conditioning stimuli and monitor rat activity without the stress of transferring them to a different chamber.
Article Abstract
We have developed an apparatus and techniques that permit repeated, undisturbed blood sampling and concurrent assessment of activity in rats. The apparatus also allows experimental control of conditioning stimuli and contingencies without the need to transfer the rat to a separate chamber. In the experimental apparatus, body weights remain stable at approximately 90% of the original body weight. Plasma corticosterone and prolactin levels in the apparatus are comparable to levels obtained in undisturbed free-ranging rats and remain at basal levels for the 7 day duration of this experiment. Additionally, circadian activity rhythms in the apparatus are similar to those seen in free-ranging rats. This technique has potential applications for investigators who need to be able to control shock delivery, monitor activity, and sample blood without disturbing rats.
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| http://dx.doi.org/10.1016/0031-9384(89)90186-8 | DOI Listing |
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