Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896060 | PMC |
| http://dx.doi.org/10.1083/jcb.201605072 | DOI Listing |
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