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Simplifying Mismatch Repair Deficiency Screening in Endometrial Adenocarcinoma: Immunohistochemistry with Two-Antibody Panel (PMS2 and MSH6).
Asian Pac J Cancer Prev
October 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Article Synopsis
- The study focuses on comparing a simplified two-antibody method (PMS2 and MSH6) against a traditional four-antibody method for diagnosing mismatch repair deficiency (dMMR) in endometrial adenocarcinoma, which is important for identifying Lynch syndrome and guiding treatments.
- Conducting a retrospective analysis of 304 endometrial cancer cases from 2013 to 2022, the two-antibody method identified dMMR in 26.6% of samples, showing a high agreement (98.8%) with the four-antibody panel, with only one case having differing results.
- The findings suggest that the two-antibody approach could serve as an effective
Comparative Analysis of Three Surgical Instruments in the Treatment of High Critical Enucleation of Prostate.
Asian Pac J Cancer Prev
September 2024
Lincoln University College, Malaysia.
Article Synopsis
- A study was done to see how well three surgical tools (red laser, green laser, and plasma) worked for treating a prostate problem called benign prostatic hyperplasia (BPH).
- Out of 237 patients, those who used red and green lasers had shorter operation times and lost less blood compared to the plasma tool.
- All tools were safe, but the lasers were better at reducing complications and improving patient health after surgery.
Early Symptom Patterns by Tumor Laterality, Age at Onset, Stage, and Symptom-to-Treatment Initiation in Patients with Colorectal Cancer.
Asian Pac J Cancer Prev
August 2024
Pathgen Diagnostic Technology, Invitro Diagnostic Laboratory, National Research and Innovation Agency Republic of Indonesia, Ir. Soekarno Science and Techno Park, Bogor, Indonesia.
Background: In Indonesia incidence of colorectal cancer (CRC) remains high. Information about early symptoms that can offer clinicians insights for timely diagnosis, prompt referral and quick treatment decisions is very limited. This study aims to examine the pattern of CRC early symptoms and its association with tumor laterality, age at onset, metastatic status, and symptom-to-treatment initiation (STI) duration and delay.
View Article and Find Full Text PDFOxidative Stress Assessment of Noise Exposure in the Workers Using Hearing Protection in a Pressing Industry.
Asian Pac J Cancer Prev
June 2024
Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background And Objective: Exposure to noise by generation of free radicals causes oxidative stress in body. The aim of this study was the evaluation of oxidative stress in workers who have used hearing protection devices during working time.
Material And Method: Pressing workers (n=24) of a home appliance industry were studied using hearing protection devices to reduce noise exposure.
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