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| http://dx.doi.org/10.1016/j.bbagen.2016.06.001 | DOI Listing |
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Analysis of chicken LGALSL (galectin-related protein) gene's proximal promoter and its control by Krüppel-like factors 3 and 7.
Gene
January 2025
Department of Veterinary Sciences, Physiological Chemistry, Ludwig-Maximilians-University Munich, Lena-Christ-Str. 48, 82152 Planegg-Martinsried, Germany. Electronic address:
The Galectin-Related Protein (GRP), encoded by the LGALSL gene, assigned to the protein family of β-galactoside-binding Galectins, has lost carbohydrate-binding abilities. Its chicken homolog (C-GRP) occurs in the bursa of Fabricius' epithelial and B cells. Our study investigates the unknown regulatory mechanisms controlling its expression by analyzing the promoter region of the chicken (C-)LGALSL gene in chicken cells.
View Article and Find Full Text PDFA brief history of galectin evolution.
Front Immunol
July 2023
Glycobiology Unit, Institute of Reproductive Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.
Article Synopsis
- Galectins are diverse carbohydrate-binding proteins found in vertebrates, with connections to primitive Bilateria, revealing their evolutionary history through genomic analysis.
- The ancestral galectin is traced back to scallops, showing characteristics similar to galectin-8, which includes specific binding properties.
- The research offers new insights into the evolution of galectin family members in vertebrates, particularly highlighting the role of Cyclostomata and the neglected galectin-related protein 2.
Molecular characterization, immune responses, and functional aspects of atypical prototype galectin from redlip mullet (Liza haematocheila) as a pattern recognition receptor in host immune defense system.
Fish Shellfish Immunol
February 2023
Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea. Electronic address:
Galectins are a family of lectins that are widely distributed β-galactoside-binding proteins identified in diverse organisms. Galectin family have appeared as pattern recognition receptors (PRRs) responsible for initiating and controlling the innate immunity. The present study aimed to study the binding ability and potential role in PRRs of galectin-related protein B-like (LhGal B-like) from redlip mullet (Liza haematocheila) involved in the host immune responses.
View Article and Find Full Text PDFCharacterization and functional analysis of a galectin-related protein B from Nile tilapia involved in the immune response to bacterial infection.
J Fish Dis
February 2021
College of Fishery, Guangdong Provincial Engineering Laboratory for Mariculture Organism Breeding, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineering Guangdong Laboratory, Guangdong Ocean University, Zhanjiang, China.
Galectin-related protein is a kind of lectin without canonical activity that regulates cell adhesion and cell growth. In this study, a novel galectin-related protein B (OnGRPB) was identified from Nile tilapia (Oreochromis niloticus). The open reading frame of OnGRPB was 438 bp and encoded a peptide of 145 amino acids.
View Article and Find Full Text PDFChicken GRIFIN: binding partners, developmental course of localization and activation of its lens-specific gene expression by L-Maf/Pax6.
Cell Tissue Res
March 2019
Institute for Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Veterinärstr. 13, 80539, Munich, Germany.
Tissue lectins appear to be involved in a broad range of physiological processes, as reflected for the members of the family of galectins by referring to them as adhesion/growth-regulatory effectors. In order to clarify the significance of galectin presence, key challenges are to define their binding partners and the profile of localization. Having identified the chicken galectin-related interfiber protein (C-GRIFIN) as lens-specific protein present in the main body of adult lens, we here report its interaction with lens proteins in ligand blotting.
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