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Superelastic bamboo cellulose nanofiber based carbon aerogel with layered network microstructure for high sensitivity piezoresistive sensor.
Int J Biol Macromol
January 2025
School of Materials & Chemistry Architecture, Anhui Agricultural University, Anhui Healthy Sleep Home Furnishings Engineering Research Center, Hefei 230036, China. Electronic address:
Carbon aerogels, characterized by their high porosity and superior electrical performance, present significant potential for the development of highly sensitive pressure sensors. However, facile and cost-effective fabrication of biomass-based carbon aerogels that concurrently possess high sensitivity, high elasticity, and excellent fatigue resistance remains a formidable challenge. Herein, a piezoresistive sensor with a layered network microstructure (BCNF-rGO-CS) was successfully fabricated using bamboo nanocellulose fiber (BCNF), chitosan (CS), and graphene oxide (GO) as raw materials.
View Article and Find Full Text PDFGenetically Encoded Biosensors for Constrained Biological Functions in Probiotic Nissle.
ACS Synth Biol
January 2025
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian 361102, China.
The probiotic Nissle (EcN) is an exceptional strain that has attracted significant attention not only for its clinical efficacy in the treatment and prevention of gastrointestinal disorders but also as a burgeoning microbial chassis for living therapeutic applications. However, there is an immediate necessity to develop conditional expression systems that confine the activity of EcN specifically in the gastrointestinal tract, to avoid influencing the environment. Here, we constructed two genetically encoded interchangeable sensors responsive to body temperature at 37 °C, and small molecules such as protocatechuic acid (PCA), a metabolite found in green tea.
View Article and Find Full Text PDFGenome-Wide Association Study of Body Weight Traits in Texel and Kazakh Crossbred Sheep.
Genes (Basel)
November 2024
Key Laboratory of Animal Biotechnology of Xinjiang, Key Laboratory of Genetics Breeding and Reproduction of Grass Feeding Livestock, Minisitry of Agriculture and Rural Affairs of the People's Republic of China, Institute of Biotechnology, Xinjiang Academy of Animal Science, Urumqi 830000, China.
Originating from the cold and arid regions of northwestern China, Kazakh sheep are dual-purpose breeds optimized for both meat and fat production. In contrast, Texel sheep are internationally recognized for their high-quality meat and exceptional flavor. Previous studies have indicated that the hybrids of Texel and Kazakh sheep exhibit significant quality advantages.
View Article and Find Full Text PDFSynthesis and antitumor effects of novel betulinic acid derivatives bearing electrophilic moieties.
Bioorg Med Chem
January 2025
Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China; Ningbo Institute of Dalian University of Technology, Ningbo 315016, China. Electronic address:
Betulinic acid (BA) is a kind of naturally occurring lupane pentacyclic triterpenoid, possessing various biological activities including antiviral, anti-inflammatory and antitumor activity. Covalent inhibitors, characterized by electrophilic warheads that form covalent bonds with specific amino acid residues of target proteins, have garnered enormous attention in anticancer agent discovery over the past decade owing to their exceptional selectivity and efficacy. In this study, BA was structurally modified with electrophilic groups, and 23 derivatives of BA were synthesized.
View Article and Find Full Text PDFThrow out an oligopeptide to catch a protein: Deep learning and natural language processing-screened tripeptide PSP promotes Osteolectin-mediated vascularized bone regeneration.
Bioact Mater
April 2025
Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stom, Shanghai, 200011, China.
Article Synopsis
- Angiogenesis is crucial for bone regeneration, but traditional cytokine therapies face challenges like high costs and safety concerns.
- Using Deep Learning and Natural Language Processing, researchers developed a new algorithm to identify promising pro-angiogenic peptides from disordered regions of proteins, highlighting the potential for safer bioactive peptides.
- One notable tripeptide, PSP, significantly promotes vascularization and osteogenic differentiation in stem cells, showcasing its role as a 'priming' agent that enhances the body's natural bone formation processes.
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