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International myeloma working group immunotherapy committee recommendation on sequencing immunotherapy for treatment of multiple myeloma.
Leukemia
January 2025
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
T-cell redirecting therapy (TCRT), specifically chimeric antigen receptor T-cell therapy (CAR T-cells) and bispecific T-cell engagers (TCEs) represent a remarkable advance in the treatment of multiple myeloma (MM). There are several products available around the world and several more in development targeting primarily B-cell maturation antigen (BCMA) and G protein-coupled receptor class C group 5 member D (GRPC5D). The relatively rapid availability of multiple immunotherapies brings the necessity to understand how a certain agent may affect the safety and efficacy of a subsequent immunotherapy so MM physicians and patients can aim at optimal sequential use of these therapies.
View Article and Find Full Text PDFPiezoelectric biosensor with dissipation monitoring enables the analysis of bacterial lytic agent activity.
Sci Rep
January 2025
Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Antibiotic-resistant strains of Staphylococcus aureus pose a significant threat in healthcare, demanding urgent therapeutic solutions. Combining bacteriophages with conventional antibiotics, an innovative approach termed phage-antibiotic synergy, presents a promising treatment avenue. However, to enable new treatment strategies, there is a pressing need for methods to assess their efficacy reliably and rapidly.
View Article and Find Full Text PDFGreen building development utilising modified fired clay bricks and eggshell waste.
Sci Rep
January 2025
PV Unit, Solar and Space Research Department, National Research Institute of Astronomy and Geophysics (NRIAG), Helwan, Cairo, Egypt.
The inadequate thermal insulation of the building envelope contributes significantly to the high power consumption of air conditioners in houses. A crucial factor in raising a building's energy efficiency involves utilizing bricks with high thermal resistance. This issue is accompanied by another critical challenge: recycling and disposing of waste in a way that is both economically and environmentally beneficial, including using it to fuel industrial growth, in order to reduce the harmful effects of waste on the environment as waste generation in our societies grows.
View Article and Find Full Text PDFHow should the advancement of large language models affect the practice of science?
Proc Natl Acad Sci U S A
February 2025
Max Planck Institute for Biological Cybernetics, Tübingen, Baden-Württemberg 72076, Germany.
Large language models (LLMs) are being increasingly incorporated into scientific workflows. However, we have yet to fully grasp the implications of this integration. How should the advancement of large language models affect the practice of science? For this opinion piece, we have invited four diverse groups of scientists to reflect on this query, sharing their perspectives and engaging in debate.
View Article and Find Full Text PDFEthics Committees' Practices in Healthcare, Banking and Research: Key Requirements for Their Functionality.
J Eval Clin Pract
February 2025
Institute of the History of Medicine and Ethics in Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Rationale: To meet concerns about ethical and unethical behavior in their work environments and workplaces, organizations began establishing ethics programs that contain ethics committees (ECs). There is now a tradition and diverse use of ECs for ethical decision-making in many different organizational settings. In addition, ECs have been subject to many publications in books and articles in the scientific literature.
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