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Aim: Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC).
Materials & Methods: Six SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-27a rs895819, miR-423 rs6505162, miR-608 rs4919510, miR-149 rs2292832) were genotyped in 898 histologically confirmed GC cases and 992 controls in this hospital-based case-control study.
Results: The G/G genotype of rs2910164 was associated with reduced risk of GC (odds ratio: 0.76, 95% CI: 0.60-0.97; p = 0.024). Meanwhile, in 838 GC cases receiving radical tumorectomy, cases bearing the G/G genotype of rs2910164 had shorter survival time comparing to cases with C/C or C/G genotype (hazard ratio: 1.36, 95% CI: 1.04-1.78, p = 0.023).
Conclusion: rs2910164 of miR-146a is associated with GC.
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| http://dx.doi.org/10.2217/fon-2016-0224 | DOI Listing |
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