AI Article Synopsis
- SCUBE1 is a protein that serves as a marker for coagulation and is linked to the prognosis of critical illnesses, specifically in patients with aneurysmal subarachnoid hemorrhage (aSAH).
- Researchers analyzed serum SCUBE1 levels in 125 aSAH patients compared to 125 controls, finding significantly higher levels in patients along with strong correlations to established clinical scoring systems.
- The study concludes that elevated SCUBE1 levels could be a valuable predictor of poor outcomes in aSAH patients, potentially helping to identify those at greater risk of mortality or unfavorable recovery.
Article Abstract
Background: Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1), a marker for coagulation, is correlated with prognosis of some critical illnesses. The current study was designed to investigate the potential prognostic value of serum SCUBE1 concentrations in patients with aneurysmal subarachnoid hemorrhage (aSAH).
Methods: Serum SCUBE1 concentrations of 125 patients and 125 controls were determined. Multivariate analyses were performed to identify independent risk factors for 6-month mortality, overall survival and unfavorable outcome (Glasgow Outcome Scale score of 1-3).
Results: Serum SCUBE1 concentrations were significantly higher in patients than in controls (17.7±7. vs. 1.2±0.4ng/ml, P<0.001) and were associated highly with World Federation of Neurological Surgeons (WFNS) scores (t=5.109, P<0.001) and modified Fisher scores (t=4.329, P<0.001). SCUBE1 emerged as an independent predictor for 6-month clinical outcomes. It had similar area under receiver operating characteristic curve (AUC) to WFNS scores and modified Fisher scores. Moreover, it could markedly improve the AUC of WFNS scores and modified Fisher scores to predict 6-month unfavorable outcome.
Conclusion: Enhanced SCUBE1 concentrations are correlated with increasing severity and poor outcomes of aSAH patients, indicating SCUBE1 might have the potential to identify aSAH patients at risk of poor prognosis.
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| http://dx.doi.org/10.1016/j.cca.2016.06.002 | DOI Listing |
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