AI Article Synopsis
- The study aimed to compare the dose distribution of carbon-ion beam therapy for pancreatic cancer using both passive and scanning irradiation techniques.
- Thirteen patients were treated using four different plans, each delivering the same target dose while evaluating effects on both the cancerous area and surrounding organs.
- Results indicated that the three-field scanning approach not only minimized damage to critical digestive organs but also showed promise in improving overall treatment safety for patients.
Article Abstract
Purpose: To compare carbon-ion beam dose distribution between passive and scanning radiation therapies for locally advanced pancreatic cancer.
Materials And Methods: Thirteen pancreatic cancer patients were included in this study. Four types of treatment planning with respiratory gating were calculated for each patient: a four-field box with passive irradiation (Plan 1), scanning irradiation (Plan 2), a three-field (150°, 180° and 210°) protocol with passive irradiation (Plan 3), and scanning irradiation (Plan 4). The irradiation plans each delivered 55.2Gy (RBE) to the planning target volume (PTV) and were compared with respect to doses to the PTV and organs at risk (OARs).
Results: Plan 3 exceeded the dose assessment metrics to the spinal cord. Scanning irradiation plans (Plan 2 and, particularly, Plan 4) offered significantly reduced dosage to the stomach and the duodenum compared with passive irradiation.
Conclusion: Three-field oblique scanning irradiation for pancreatic cancer has the potential to reduce gastrointestinal exposure and influence of peristalsis on dose distribution.
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| http://dx.doi.org/10.1016/j.radonc.2016.04.026 | DOI Listing |
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