We explored the anti-cancer capacity of (-)-oleocanthal in human hepatocellular carcinoma (HCC). (-)-Oleocanthal inhibited proliferation and cell cycle progression and induced apoptosis in HCC cells in vitro and suppressed tumor growth in an orthotopic HCC model. (-)-Oleocanthal also inhibited HCC cell migration and invasion in vitro and impeded HCC metastasis in an in vivo lung metastasis model. ( )-Oleocanthal acted by inhibiting epithelial-mesenchymal transition (EMT) through downregulation Twist, which is a direct target of STAT3. (-)-Oleocanthal also reduced STAT3 nuclear translocation and DNA binding activity, ultimately downregulating its downstream effectors, including the cell cycle protein Cyclin D1, the anti-apoptotic proteins Bcl-2 and survivin, and the invasion-related protein MMP 2. Overexpression of constitutively active STAT3 partly reversed the anti cancer effects of (-)-oleocanthal, which inhibited STAT3 activation by decreasing the activities of JAK1 and JAK2 and increasing the activity of SHP-1. These data suggest that (-)-oleocanthal may be a promising candidate for HCC treatment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190038PMC
http://dx.doi.org/10.18632/oncotarget.9782DOI Listing

Publication Analysis

Top Keywords

--oleocanthal inhibited
12
human hepatocellular
8
hepatocellular carcinoma
8
cell cycle
8
--oleocanthal
7
hcc
6
stat3
5
--oleocanthal inhibits
4
inhibits growth
4
growth metastasis
4

Similar Publications

Neuroinflammation is a critical aspect of various neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. This study investigates the anti-neuroinflammatory properties of oleocanthal and its oxidation product, oleocanthalic acid, using the BV-2 cell line activated with lipopolysaccharide. Our findings revealed that oleocanthal significantly inhibited the production of pro-inflammatory cytokines and reduced the expression of inflammatory genes, counteracted oxidative stress induced by lipopolysaccharide, and increased cell phagocytic activity.

View Article and Find Full Text PDF
Article Synopsis
  • - The paper discusses the significant cultural and health-related roles of olive oil in Europe, particularly its well-known health benefits and potential anti-cancer properties due to compounds like oleocanthal, oleacein, and oleuropein.
  • - A systematic review of 4037 articles identified 88 that focused on the mechanisms of these key bioactive compounds in preventing cancer, highlighting their ability to inhibit cell growth, induce cell death, and disrupt tumor development.
  • - The findings suggest that the consumption of olive oil is linked to a lower risk of cancer, and the research may open new avenues for combining olive-derived compounds with existing cancer treatments to create innovative nutrition-focused anti-cancer strategies.
View Article and Find Full Text PDF

In a landmark study, oleocanthal (OLC), a major phenolic in extra virgin olive oil (EVOO), was found to possess anti-inflammatory activity similar to ibuprofen, involving inhibition of cyclooxygenase (COX) enzymes. EVOO is a rich source of bioactive compounds including fatty acids and phenolics; however, the biological activities of only a small subset of compounds associated with have been explored. Here, the OliveNet library (consisting of over 600 compounds) was utilized to investigate olive-derived compounds as potential modulators of the arachidonic acid pathway.

View Article and Find Full Text PDF

Extra Virgin Olive Oil's Main Components' Antioxidant Activity and in Silico Effect on AKT1.

Chem Biodivers

September 2024

Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, 06000, Algérie.

The study compared the chemical composition of various olive oils from the northern Algerian province of Bejaia. The research focused on the antioxidant activities of the oil's main constituents and their ability to inhibit the AKT1 protein, which is implicated in the development of colorectal cancer. The findings revealed that all of the examined oils fell within the extra virgin olive oil (EVOO) category and exhibited a high oleic acid content, particularly for samples from wild olives.

View Article and Find Full Text PDF

The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds. Over 200 phenolic compounds have been associated with , and of these, only a relatively small fraction have been characterised. Utilising the OliveNet library, phenolic compounds were investigated as potential inhibitors of the epigenetic modifier lysine-specific demethylase 1 (LSD1).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!