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A Water-stable Hydrogen-Bonded Organic framework (HOF) for Selective Sensing of Antibiotics in Aqueous Medium.
Chemistry
January 2025
IIT Kharagpur: Indian Institute of Technology Kharagpur, Dept of Chemistry, IIT Kharagpur, 721302, Kharagpur, INDIA.
Although metal organic frameworks (MOFs) and covalent organic frameworks (COFs) have been extensively used as fluorescent-based antibiotic sensors, newly developed hydrogen-bonded organic frameworks (HOFs) are largely unexplored toward this direction. To realize this, the luminescent HOFs must be stable in water as the analytes are mostly found in water-based effluents in environments. In addition, HOFs should be equipped with specific recognition sites in order to direct the discrimination among the antibiotics.
View Article and Find Full Text PDFChemotherapy-induced neuropathic pain (CINP) is a common adverse effect of antineoplastic drugs, often leading to dose reduction, treatment delays, or cessation of chemotherapy. Chemotherapy agents, like paclitaxel (PTX), damage the somatosensory nervous system by inducing neuroinflammation and oxidative stress, resulting in the sensitization of sensory neurons. Quercetin (QCT), known for its anti-inflammatory, antioxidant, and neuroprotective properties, is investigated for various neurological disorders.
View Article and Find Full Text PDFSmall fiber neuropathy in the post-COVID condition and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical significance and diagnostic challenges.
Eur J Neurol
February 2025
Neurodegenerative Diseases Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Background: Patients with post-COVID condition (PCC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience symptoms potentially associated with small fiber neuropathy (SFN).
Methods: A sample of 90 participants, comprising 30 PCC patients, 30 ME/CFS patients, and 30 healthy controls (HC), matched by sex and age, was assessed. Neuropathic, autonomic, and fatigue symptoms were measured with TaskForce Monitor, the Sudoscan, heat and cold evoked potentials, In Vivo Corneal Confocal Microscopy (IVCCM), and specialized questionaries.
The role of conscious attention in auditory statistical learning: Evidence from patients with impaired consciousness.
iScience
January 2025
Cognitive Neuroimaging Unit U992, CNRS, INSERM, CEA, DRF/Institut Joliot, Université Paris-Saclay, NeuroSpin Center, 91191 Gif/Yvette, France.
The need for attention to enable statistical learning is debated. Testing individuals with impaired consciousness offers valuable insight, but very few studies have been conducted due to the difficulties inherent in such studies. Here, we examined the ability of patients with varying levels of disorders of consciousness (DOC) to extract statistical regularities from an artificial language composed of randomly concatenated pseudowords by measuring frequency tagging in EEG.
View Article and Find Full Text PDFDifferential Neuronal Activation of Nociceptive Pathways in Neuropathic Pain After Spinal Cord Injury.
Cell Mol Neurobiol
January 2025
Department of Neurology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
Neuropathic pain, a prevalent complication following spinal cord injury (SCI), severely impairs the life quality of patients. No ideal treatment exists due to incomplete knowledge on underlying neural processes. To explore the SCI-induced effect on nociceptive circuits, the protein expression of c-Fos was analyzed as an indicator of neuronal activation in a rat contusion model exhibiting below-level pain.
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